A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant
A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant
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- creativework.keywords - en
- Taxus
- Fungi
- Endophytes
- Paclitaxel
- Biosynthesis
- Antifungal agents
- creativework.keywords - fr
- If
- Champignons
- Endophytes
- Paclitaxel
- Biosynthèse
- Antifongiques
- dc.contributor.author
- Soliman, Sameh S. M.
- Trobacher, Christopher P.
- Tsao, Rong
- Greenwood, John S.
- Raizada, Manish N.
- dc.date.accepted
- 2013-06-11
- dc.date.accessioned
- 2026-01-20T13:15:56Z
- dc.date.available
- 2026-01-20T13:15:56Z
- dc.date.issued
- 2013-06-26
- dc.date.submitted
- 2013-02-01
- dc.description.abstract - en
- Background Taxol is an anti-cancer drug harvested from Taxus trees, proposed ecologically to act as a fungicide. Taxus is host to fungal endophytes, defined as organisms that inhabit plants without causing disease. The Taxus endophytes have been shown to synthesize Taxol in vitro, providing Taxus with a second potential biosynthetic route for this protective metabolite. Taxol levels in plants vary 125-fold between individual trees, but the underlying reason has remained unknown. Results Comparing Taxus trees or branches within a tree, correlations were observed between Taxol content, and quantity of its resident Taxol-producing endophyte, Paraconiothyrium SSM001. Depletion of fungal endophyte in planta by fungicide reduced plant Taxol accumulation. Fungicide treatment of intact plants caused concomitant decreases in transcript and/or protein levels corresponding to two critical genes required for plant Taxol biosynthesis. Taxol showed fungicidal activity against fungal pathogens of conifer wood, the natural habitat of the Taxol-producing endophyte. Consistent with other Taxol-producing endophytes, SSM001 was resistant to Taxol. Conclusions These results suggest that the variation in Taxol content between intact Taxus plants and/or tissues is at least in part caused by varying degrees of transcriptional elicitation of plant Taxol biosynthetic genes by its Taxol-producing endophyte. As Taxol is a fungicide, and the endophyte is resistant to Taxol, we discuss how this endophyte strategy may be to prevent colonization by its fungal competitors but at minimal metabolic cost to itself.
- dc.identifier.citation
- Soliman, S. S. M., Trobacher, C. P., Tsao, R., Greenwood, J. S., & Raizada, M. N. (2013). A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant. BMC Plant Biology, 13, Article 93. https://doi.org/10.1186/1471-2229-13-93
- dc.identifier.doi
- https://doi.org/10.1186/1471-2229-13-93
- dc.identifier.issn
- 1471-2229
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/4158
- dc.language.iso
- en
- dc.publisher - en
- Springer Nature
- dc.publisher - fr
- Springer Nature
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Plants
- Fungicides
- dc.subject - fr
- Plante
- Fongicide
- dc.subject.en - en
- Plants
- Fungicides
- dc.subject.fr - fr
- Plante
- Fongicide
- dc.title - en
- A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 93
- local.article.journaltitle - en
- BMC Plant Biology
- local.article.journalvolume
- 13
- local.pagination
- 1-10
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
- local.requestdoi - en
- No
- local.requestdoi - fr
- No
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