Lumpy skin disease : history, current understanding and research gaps in the context of recent geographic expansion

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creativework.keywords - en

Lumpy skin disease

Epidemiology

Dermatose nodulaire contagieuse bovine

Épidémiologie

Phylogenèse

creativework.keywords - fr

Phylogeny

Recombinaison génétique

Genetic recombination

Animaux--Maladies infectieuses--Transmission

Communicable diseases in animals--Transmission

dc.contributor.author

Mazloum, Ali

Van Schalkwyk, Antoinette

Babiuk, Shawn

Venter, Estelle

Wallace, David B.

Sprygin, Alexander

dc.date.accepted

2023-09-28

dc.date.accessioned

2024-08-16T19:32:53Z

dc.date.available

2024-08-16T19:32:53Z

dc.date.issued

2023-11-02

dc.date.submitted

2023-07-25

dc.description.abstract - en

Lumpy skin disease is recognized as a transboundary and emerging disease of cattle, buffaloes and other wild ruminants. Being initially restricted to Africa, and since 1989 the Middle East, the unprecedented recent spread across Eurasia demonstrates how underestimated and neglected this disease is. The initial identification of the causative agent of LSD as a poxvirus called LSD virus, was well as findings on LSDV transmission and epidemiology were pioneered at Onderstepoort, South Africa, from as early as the 1940s by researchers such as Weiss, Haig and Alexander. As more data emerges from an ever-increasing number of epidemiological studies, previously emphasized research gaps are being revisited and discussed. The currently available knowledge is in agreement with the previously described South African research experience that LSDV transmission can occur by multiple routes, including indirect contact, shared water sources and arthropods. The virus population is prone to molecular evolution, generating novel phylogenetically distinct variants resulting from a diverse range of selective pressures, including recombination between field and homologous vaccine strains in cell culture that produce virulent recombinants which pose diagnostic challenges. Host restriction is not limited to livestock, with certain wild ruminants being susceptible, with unknown consequences for the epidemiology of the disease.

dc.identifier.citation

Mazloum, A., Van Schalkwyk, A., Babiuk, S., Venter, E., Wallace, D. B., & Sprygin, A. (2023). Lumpy skin disease : history, current understanding and research gaps in the context of recent geographic expansion. Frontiers in Microbiology, 14, Article 1266759. https://doi.org/10.3389/fmicb.2023.1266759

dc.identifier.doi

https://doi.org/10.3389/fmicb.2023.1266759

dc.identifier.issn

1664-302X

dc.identifier.uri

https://open-science.canada.ca/handle/123456789/2846

dc.language.iso

en

dc.publisher

Frontiers Media SA

dc.rights - en

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights - fr

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights.openaccesslevel - en

Gold

dc.rights.openaccesslevel - fr

Or

dc.rights.uri - en

https://creativecommons.org/licenses/by/4.0/

dc.rights.uri - fr

https://creativecommons.org/licenses/by/4.0/deed.fr

dc.subject - en

Nature and environment

Health and safety

dc.subject - fr

Nature et environnement

Santé et sécurité

dc.subject.en - en

Nature and environment

Health and safety

dc.subject.fr - fr

Nature et environnement

Santé et sécurité

dc.title - en

Lumpy skin disease : history, current understanding and research gaps in the context of recent geographic expansion

dc.type - en

Article

dc.type - fr

Article

local.acceptedmanuscript.articlenum

1266759

local.article.journaltitle

Frontiers in Microbiology

local.article.journalvolume

14

local.pagination

1-20

local.peerreview - en

Yes

local.peerreview - fr

Oui

local.requestdoi

No

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