Humoral responses in the Omicron era following 3-dose SARS-CoV-2 vaccine series in kidney transplant recipients
Humoral responses in the Omicron era following 3-dose SARS-CoV-2 vaccine series in kidney transplant recipients
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- dc.contributor.author
- McEvoy, Caitríona M.
- Hu, Queenie
- Abe, Kento T.
- Yau, Kevin
- Oliver, Matthew J.
- Levin, Adeera
- Gingras, Anne-Claude
- Hladunewich, Michelle A.
- Yuen, Darren A.
- dc.date.accessioned
- 2025-02-14T16:20:17Z
- dc.date.available
- 2025-02-14T16:20:17Z
- dc.date.issued
- 2022-12-07
- dc.description.abstract - en
- <p>Kidney transplant recipients (KTRs) have a diminished response to SARS-CoV-2 vaccination compared with immunocompetent individuals. Deeper understanding of antibody responses in KTRs following third-dose vaccination would enable identification of those who remain unprotected against Omicron.</p> <p>Methods: <br>We profiled antibody responses in KTRs pre- and at 1 and 3 mo post-third-dose SARS-CoV-2 mRNA-based vaccine. Binding antibody levels were determined by ELISA. Neutralization against wild type, Beta, Delta, and Omicron (BA.1) variants was determined using a SARS-CoV-2 spike-pseudotyped lentivirus assay.</p> <p>Results: <br>Forty-four KTRs were analyzed at 1 and 3 mo (n = 26) post-third dose. At 1 mo, the proportion of participants with a robust antibody response had increased significantly from baseline, but Omicron-specific neutralizing antibodies were detected in just 45% of KTRs. Median binding antibody levels declined at 3 mo, but the proportion of KTRs with a robust antibody response was unchanged; 38.5% KTRs maintained Omicron-specific neutralization at 3 mo. No clinical variables were significantly associated with Omicron-neutralizing antibodies, but antireceptor binding domain titers appeared to identify those with Omicron-specific neutralizing capacity.</p> <p>Conclusions: <br>Over 50% of KTRs lack Omicron-specific neutralization capacity 1 mo post-third mRNA-vaccine dose. Antibody levels of responders were well preserved at 3 mo. Anti receptor binding domain antibody titers may identify patients with a detectable Omicron-neutralizing antibody response.</p>
- dc.identifier.doi
- 10.1097/TXD.0000000000001401
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/3446
- dc.language.iso
- en
- dc.publisher - en
- Wolters Kluwer
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- Coronavirus diseases
- Organ transplantation
- dc.subject - fr
- Santé
- Maladie à coronavirus
- Transplantation d'organes
- dc.subject.en - en
- Health
- Coronavirus diseases
- Organ transplantation
- dc.subject.fr - fr
- Santé
- Maladie à coronavirus
- Transplantation d'organes
- dc.title - en
- Humoral responses in the Omicron era following 3-dose SARS-CoV-2 vaccine series in kidney transplant recipients
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- e1401
- local.article.journalissue
- 1
- local.article.journaltitle - en
- Transplantation Direct
- local.article.journalvolume
- 9
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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