Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort: study methodology and cohort profile
Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort: study methodology and cohort profile
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- dc.contributor.author
- Azeez, Rilwan
- Lotoski, Larisa
- Dubeau, Aimée
- Medeleanu, Maria
- Winsor, Geoffrey L.
- Brinkman, Fiona S. L.
- Goguen, Stephanie
- Cameron, Emily E.
- Roos, Leslie
- Simons, Elinor
- Moraes, Theo J.
- Mandhane, Piush J.
- Turvey, Stuart E.
- Bolotin, Shelly
- Wright, Kim
- McNeil, Deborah
- Patrick, David M.
- Bullard, Jared
- Langlois, Marc-André
- Arnold, Corey R.
- Galipeau, Yannick
- Pelchat, Martin
- Doucas, Natasha
- Subbarao, Padmaja
- Azad, Meghan B.
- Rodriquez, Natalie
- Reyna, Myrtha E.
- Freitas, Tyler
- dc.date.accessioned
- 2025-02-04T17:10:16Z
- dc.date.available
- 2025-02-04T17:10:16Z
- dc.date.issued
- 2022-10-21
- dc.description.abstract - en
- <p>Background: <br>The COVID-19 pandemic is affecting all Canadian families, with some impacted differently than others. Our study aims to: 1) determine the prevalence and transmission of SARSCoV-2 infection among Canadian families, 2) identify predictors of infection susceptibility and severity of SARS-CoV-2 and 3) identify health and psychosocial impacts of the COVID-19 pandemic. </p> <p>Methods: <br>This study builds upon the CHILD Cohort Study, an ongoing multi-ethnic general population prospective cohort consisting of 3454 Canadian families with children born in Vancouver, Edmonton, Manitoba, and Toronto between 2009-12. During the pandemic, 1462 CHILD households (5378 individuals) consented to participate in the CHILD COVID-19 Add-On Study involving: (1) brief biweekly surveys about COVID-19 symptoms and testing; (2) quarterly questionnaires assessing COVID-19 exposure, testing and vaccination status, physical and mental health, and pandemicdriven life changes; (3) in-home biological sampling kits to collect blood and stool. Mean ages were 9 years (range 0-17) for children and 43 years (range 18-85) for adults. Prevalence of SARS-CoV-2 infection will be estimated from survey data and confirmed through serology testing. We will combine these new data with a wealth of pre-pandemic CHILD data and use multivariate modelling and machine learning methods to identify risk and resilience factors for susceptibility and severity to the direct and indirect effects of the pandemic. </p> <p>Interpretation: <br>Our short-term findings will inform key stakeholders and knowledge users to shape current and future pandemic responses. Additionally, thisstudy provides a unique resource to study the long-term impacts of the pandemic as the CHILD Cohort Study continues. </p>
- dc.identifier.doi
- 10.1101/2022.10.19.22281242
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/3392
- dc.language.iso
- en
- dc.publisher - en
- medRxiv
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- Coronavirus diseases
- Psychology
- dc.subject - fr
- Santé
- Maladie à coronavirus
- Psychologie
- dc.subject.en - en
- Health
- Coronavirus diseases
- Psychology
- dc.subject.fr - fr
- Santé
- Maladie à coronavirus
- Psychologie
- dc.title - en
- Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort: study methodology and cohort profile
- dc.type - en
- Submitted manuscript
- dc.type - fr
- Manuscrit soumis
- local.article.journaltitle - en
- medRxiv
- local.peerreview - en
- No
- local.peerreview - fr
- Non
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