Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins
Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins
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Full item details
- creativework.keywords - en
- ACE2-Fc
- COVID-19
- CR3022 antibody
- Coronavirus
- SARS-CoV-2
- human ACE2 receptor
- neutralization
- SARS-CoV-1
- spike glycoproteins.
- dc.contributor.author
- Anand, Sai Priya
- Chen, Yaozong
- Prévost, Jérémie
- Gasser, Romain
- Beaudoin-Bussières, Guillaume
- Abrams, Cameron F.
- Pazgier, Marzena
- Finzi, Andrés
- dc.date.accessioned
- 2024-01-09T18:39:21Z
- dc.date.available
- 2024-01-09T18:39:21Z
- dc.date.issued
- 2020-09-29
- dc.description.abstract - en
- Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is responsible for the current global coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The viral entry of SARS-CoV-2 depends on an interaction between the receptor-binding domain of its trimeric spike glycoprotein and the human angiotensin-converting enzyme 2 (ACE2) receptor. A better understanding of the spike/ACE2 interaction is still required to design anti-SARS-CoV-2 therapeutics. Here, we investigated the degree of cooperativity of ACE2 within both the SARS-CoV-2 and the closely related SARS-CoV-1 membrane-bound S glycoproteins. We show that there exist differential inter-protomer conformational transitions between both spike trimers. Interestingly, the SARS-CoV-2 spike exhibits a positive cooperativity for monomeric soluble ACE2 binding when compared to the SARS-CoV-1 spike, which might have more structural restraints. Our findings can be of importance in the development of therapeutics that block the spike/ACE2 interaction.
- dc.identifier.citation
- Anand SP, Chen Y, Prévost J, Gasser R, Beaudoin-Bussières G, Abrams CF, Pazgier M, Finzi A. Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins. Viruses. 2020 Sep 29;12(10):1104. doi: 10.3390/v12101104.
- dc.identifier.doi
- https://doi.org/10.3390/v12101104
- dc.identifier.issn
- 1999-4915
- dc.identifier.pubmedID
- 33003587
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1615
- dc.language.iso
- en
- dc.publisher
- MPDI
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 1104
- local.article.journalissue
- 10
- local.article.journaltitle
- Viruses
- local.article.journalvolume
- 12
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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