Effect of chemotherapy on the microbiota and metabolome of human milk : a case report
Effect of chemotherapy on the microbiota and metabolome of human milk : a case report
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Full item details
- creativework.keywords - en
- Chemotherapy
- Breast milk--Composition
- Breast milk--Microbiology
- RNA sequencing
- creativework.keywords - fr
- Chimiothérapie
- Lait maternel--Composition
- Lait maternel--Microbiologie
- Séquençage de l'ARN
- dc.contributor.author
- Urbaniak, Camilla
- McMillan, Amy
- Angelini, Michelle
- Gloor, Gregory B.
- Sumarah, Mark
- Burton, Jeremy P.
- Reid, Gregor
- dc.date.accepted
- 2014-05-28
- dc.date.accessioned
- 2025-10-06T15:20:50Z
- dc.date.available
- 2025-10-06T15:20:50Z
- dc.date.issued
- 2014-07-11
- dc.date.submitted
- 2014-03-04
- dc.description.abstract - en
- Background Human milk is an important source of bacteria for the developing infant and has been shown to influence the bacterial composition of the neonatal gut, which in turn can affect disease risk later in life. Human milk is also an important source of nutrients, influencing bacterial composition but also directly affecting the host. While recent studies have emphasized the adverse effects of antibiotic therapy on the infant microbiota, the effects of maternal chemotherapy have not been previously studied. Here we report the effects of drug administration on the microbiota and metabolome of human milk. Methods Mature milk was collected every two weeks over a four month period from a lactating woman undergoing chemotherapy for Hodgkin’s lymphoma. Mature milk was also collected from healthy lactating women for comparison. Microbial profiles were analyzed by 16S sequencing and the metabolome by gas chromatography–mass spectrometry. Findings Chemotherapy caused a significant deviation from a healthy microbial and metabolomic profile, with depletion of genera Bifidobacterium, Eubacterium, Staphylococcus and Cloacibacterium in favor of Acinetobacter, Xanthomonadaceae and Stenotrophomonas. The metabolites docosahexaenoic acid and inositol known for their beneficial effects were also decreased. Conclusion With milk contents being critical for shaping infant immunity and development, consideration needs to be given to the impact of drugs administered to the mother and the long-term potential consequences for the health of the infant.
- dc.identifier.citation
- Urbaniak, C., McMillan, A., Angelini, M., Gloor, G. B., Sumarah, M., Burton, J. P., & Reid, G. (2014). Effect of chemotherapy on the microbiota and metabolome of human milk : a case report. Microbiome, 2, Article 24. https://doi.org/10.1186/2049-2618-2-24
- dc.identifier.doi
- https://doi.org/10.1186/2049-2618-2-24
- dc.identifier.issn
- 2049-2618
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/3907
- dc.language.iso
- en
- dc.publisher - en
- BioMed Central Ltd.
- dc.publisher - fr
- BioMed Central Ltd.
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Drugs
- Biology
- dc.subject - fr
- Médicament
- Biologie
- dc.subject.en - en
- Drugs
- Biology
- dc.subject.fr - fr
- Médicament
- Biologie
- dc.title - en
- Effect of chemotherapy on the microbiota and metabolome of human milk : a case report
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 24
- local.article.journaltitle - en
- Microbiome
- local.article.journalvolume
- 2
- local.pagination
- 1-11
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
- local.requestdoi - en
- No
- local.requestdoi - fr
- No
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