NFκB1 polymorphisms are associated with severe influenza A (H1N1) virus infection in a Canadian population

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dc.contributor.author
Mullo Mirzo, Suhrobjon
Kumar, Anand
Sharma, Naresh Kumar
Li, Lin
Balshaw, Robert
Plummer, Francis A.
Luo, Ma
Liang, Binhua
dc.date.accessioned
2023-05-30T19:28:12Z
dc.date.available
2023-05-30T19:28:12Z
dc.date.issued
2022-09-21
dc.description.abstract - en
Background: We examined associations between NFκB1 polymorphisms and influenza A (H1N1) clinical outcomes in Canadian. Methods: A total of thirty-six Caucasian patients admitted to the intensive care unit (ICU) in hospitals in Canada were recruited during the 2009 H1N1 pandemic. Genomic DNA was extracted from the whole blood samples. The NFkB1 gene was targeted for genotyping using next-generation sequencing technology—Roche 454. Results: A total of 136 single nucleotide polymorphisms (SNPs) were discovered within the NFκB1 gene. Among them, 63 SNPs were significantly enriched in patients admitted in the ICU (p < 0.05) compared with the British Caucasian population in the 1000 Genomes study. These enriched SNPs are mainly intron variants, and only two are exon SNPs from the non-transcribing portion of the NFκB1 gene. Conclusions: Genetic variations in the NFκB1 gene could influence clinical outcomes of pandemic H1N1 infections. Our findings showed that sequence variations of the NFκB1 gene might influence patient response to influenza infection.
dc.identifier.doi
https://doi.org/10.3390/microorganisms10101886
dc.identifier.issn
2076-2607
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/457
dc.language.iso
en
dc.publisher
MDPI
dc.rights - en
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights - fr
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.uri - en
https://creativecommons.org/licenses/by/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by/4.0/deed.fr
dc.subject - en
Health
dc.subject - fr
Santé
dc.subject.en - en
Health
dc.subject.fr - fr
Santé
dc.title - en
NFκB1 polymorphisms are associated with severe influenza A (H1N1) virus infection in a Canadian population
dc.type - en
Article
dc.type - fr
Article
local.article.journaltitle
Microorganisms
local.article.journalvolume
10
local.peerreview - en
Yes
local.peerreview - fr
Oui
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