Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases
Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases
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Full item details
- creativework.keywords - en
- Antibodies, Viral
- COVID-19 Vaccines*
- COVID-19* / prevention & control
- Canada
- Humans
- SARS-CoV-2
- Tumor Necrosis Factor Inhibitors
- Vaccines, Synthetic
- mRNA Vaccines
- BNT162 Vaccine
- dc.contributor.author
- Dayam, Roya M.
- Law, Jaclyn C.
- Goetgebuer, Rogier L.
- Chao, Gary Y.C.
- Abe, Kento T.
- Sutton, Mitchell
- Finkelstein, Naomi
- Stempak, Joanne M.
- Pereira, Daniel
- Croitoru, David
- Acheampong, Lily
- Rizwan, Saima
- Rymaszewski, Klaudia
- Milgrom, Raquel
- Ganatra, Darshini
- Batista, Nathalia V.
- Girard, Melanie
- Lau, Irene
- Law, Ryan
- Cheung, Michelle W.
- Rathod, Bhavisha
- Kitaygorodsky, Julia
- Samson, Reuben
- Hu, Queenie
- Hardy, W. Rod
- Haroon, Nigil
- Inman, Robert D.
- Piguet, Vincent
- Chandran, Vinod
- Silverberg, Mark S.
- Gingras, Anne-Claude
- Watts, Tania H.
- dc.date.accessioned
- 2024-07-05T19:27:02Z
- dc.date.available
- 2024-07-05T19:27:02Z
- dc.date.issued
- 2022-06-08
- dc.description.abstract - en
- BACKGROUND: Limited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMID). METHODS: This observational cohort study examined the immunogenicity of SARS-CoV-2 mRNA vaccines in adult patients with inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, or psoriatic disease, with or without maintenance immunosuppressive therapies. Ab and T cell responses to SARS-CoV-2, including neutralization against SARS-CoV-2 variants, were determined before and after 1 and 2 vaccine doses. RESULTS: We prospectively followed 150 subjects, 26 healthy controls, 9 patients with IMID on no treatment, 44 on anti-TNF, 16 on anti-TNF with methotrexate/azathioprine (MTX/AZA), 10 on anti–IL-23, 28 on anti–IL-12/23, 9 on anti–IL-17, and 8 on MTX/AZA. Ab and T cell responses to SARS-CoV-2 were detected in all participants, increasing from dose 1 to dose 2 and declining 3 months later, with greater attrition in patients with IMID compared with healthy controls. Ab levels and neutralization efficacy against variants of concern were substantially lower in anti-TNF–treated patients than in healthy controls and were undetectable against Omicron by 3 months after dose 2. CONCLUSIONS: Our findings support the need for a third dose of the mRNA vaccine and for continued monitoring of immunity in these patient groups.
- dc.description.sponsorship
- Funded by a donation from Juan and Stefania Speck and by Canadian Institutes of Health (CIHR)/COVID-Immunity Task Force (CITF) grants VR-1 172711 and VS1-175545 (to THW and ACG), CIHR FDN-143250 (to THW), GA2-177716 (to VC, ACG, and THW), and GA1-177703 (to ACG) and the CIHR rapid response network to SARS-CoV-2 variants, CoVaRR-Net (to ACG).
- dc.identifier.doi
- https://doi.org/10.1172/jci.insight.159721
- dc.identifier.issn
- 2379-3708
- dc.identifier.pubmedID
- 35471956
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2663
- dc.language.iso
- en
- dc.publisher
- American Society for Clinical Investigation
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- e159721
- local.article.journalissue
- 11
- local.article.journaltitle
- JCI Insight
- local.article.journalvolume
- 7
- local.pagination
- 1-14
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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