Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers
Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers
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- dc.contributor.author
- Abe, Kento T.
- Hu, Queenie
- Mozafarihashjin, Mohammad
- Samson, Reuben
- Manguiat, Kathy
- Robinson, Alyssia
- Rathod, Bhavisha
- Hardy, W. Rod
- Wang, Jenny H.
- Iskilova, Mariam
- Pasculescu, Adrian
- Fazel-Zarandi, Mahya
- Li, Angel
- Paterson, Aimee
- Chao, Gary
- Green, Karen
- Gilbert, Lois
- Barati, Shiva
- Haq, Nazrana
- Takaoka, Alyson
- Takaoka, Julia Garnham
- De Launay, Keelia Quinn
- Fahim, Christine
- Sheikh-Mohamed, Salma
- Arita, Yuko
- Durocher, Yves
- Marcusson, Eric G.
- Gommerman, Jennifer L.
- Ostrowski, Mario
- Colwill, Karen
- Straus, Sharon E.
- Wood, Heidi
- McGeer, Allison J.
- Gingras, Anne-Claude
- dc.date.accessioned
- 2024-01-04T14:06:40Z
- dc.date.available
- 2024-01-04T14:06:40Z
- dc.date.issued
- 2021-08
- dc.description.abstract - en
- Prioritizing Ontario’s long-term care home (LTCH) residents for vaccination against severe acute respiratory syndrome coronavirus 2 has drastically reduced their disease burden; however, recent LTCH outbreaks of variants of concern (VOCs) have raised questions regarding their immune responses. In 198 residents, mRNA vaccine dose 1 elicited partial spike and receptor binding domain antibody responses, while the second elicited a response at least equivalent to convalescent individuals in most residents. Residents administered mRNA-1273 (Moderna) mounted stronger total and neutralizing antibodyresponses than those administered BNT162b2 (Pfizer-BioNTech). Two to four weeks after dose 2, residents (n = 119, median age 88) produced 4.8–6.3-fold fewer neutralizing antibodies than staff (n = 78; median age 47) against wild-type (with D614G) pseudotyped lentivirus, and residents administered BNT162b2 produced 3.89-fold fewer neutralizing antibodies than those who received mRNA-1273. These effects were exacerbated upon serum challenge with pseudotyped VOC spike, with up to 7.94-fold reductions in B.1.351 (Beta) neutralization. Cumulatively, weaker vaccine stimulation, age/comorbidities, and the VOC produced an ~130-fold reduction in apparent neutralization titers in LTCH residents and 37.9% of BNT162b2-vaccinated residents had undetectable neutralizing antibodies to B.1.351. Continued immune response surveillance and additional vaccine doses may be required in this population with known vulnerabilities.
- dc.identifier.doi
- https://doi.org/10.1101/2021.08.06.21261721
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1403
- dc.language.iso
- en
- dc.publisher
- BMJ
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers
- dc.type - en
- Submitted manuscript
- dc.type - fr
- Manuscrit soumis
- local.peerreview - en
- No
- local.peerreview - fr
- Non
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