Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
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Full item details
- creativework.keywords - en
- COVID-19
- pediatric multisystem inflammatory syndrome
- multisystem inflammatory syndrome in children
- MIS-C
- PIMS
- PIMS-TS
- dc.contributor.author
- Striha, Megan
- Edjoc, Rojiemiahd
- Bresee, Natalie
- Atchessi, Nicole
- Waddell, Lisa
- Bennett, Terri-Lyn
- Thompson, Emily
- Jaouhari, Maryem
- Bonti-Ankomah, Samuel
- dc.date.accessioned
- 2024-04-02T15:02:34Z
- dc.date.available
- 2024-04-02T15:02:34Z
- dc.date.issued
- 2021-11
- dc.description.abstract - en
- BACKGROUND : Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome. METHODS: A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021. A database established at the Public Health Agency of Canada with COVID-19 literature was searched for articles referencing MIS-C, PIMS or Kawasaki Disease in relation to COVID-19. RESULTS: A total of 195 out of 988 articles were included in the review. The median age of MIS-C patients was between seven and 10 years of age, although children of all ages (and adults) can be affected. Multisystem inflammatory syndrome in children disproportionately affected males (58% patients), and Black and Hispanic children seem to be at an elevated risk for developing MIS-C. Roughly 62% of MIS-C patients required admission to an intensive care unit, with one in five patients requiring mechanical ventilation. Between 0% and 2% of MIS-C patients died, depending on the population and available interventions. CONCLUSION: Multisystem inflammatory syndrome in children can affect children of all ages. A significant proportion of patients required intensive care unit and mechanical ventilation and 0%-2% of cases resulted in fatalities. More evidence is needed on the role of race, ethnicity and comorbidities in the development of MIS-C.
- dc.identifier.citation
- Striha M, Edjoc R, Bresee N, Atchessi N, Waddell L, Bennett TL, Thompson E, El Jaouhari M, Bonti-Ankomah S. Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later. Can Commun Dis Rep. 2021 Nov 10;47(11):466-472. doi: 10.14745/ccdr.v47i11a04.
- dc.identifier.doi
- https://doi.org/10.14745/ccdr.v47i11a04
- dc.identifier.issn
- 1481-8531
- dc.identifier.pubmedID
- 34880708
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2211
- dc.language.iso
- en
- dc.publisher
- Public Health Agency of Canada
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journalissue
- 11
- local.article.journaltitle
- Canada Communicable Disease Report
- local.article.journalvolume
- 10
- local.pagination
- 466-472
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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