The strength in numbers : comprehensive characterization of house dust using complementary mass spectrometric techniques
- DOI
- Language of the publication
- English
- Date
- 2019-03-04
- Type
- Article
- Author(s)
- Rostkowski, Pawel
- Haglund, Peter
- Aalizadeh, Reza
- Alygizakis, Nikiforos
- Thomaidis, Nikolaos
- Beltran Arandes, Joaquin
- Bohlin Nizzetto, Pernilla
- Booij, Petra
- Budzinski, Hélène
- Brunswick, Pamela
- Covaci, Adrian
- Gallampois, Christine
- Grosse, Sylvia
- Hindle, Ralph
- Ipolyi, Ildiko
- Jobst, Karl
- Kaserzon, Sarit L.
- Leonards, Pim
- Lestremau, Francois
- Letzel, Thomas
- Magnér, Jörgen
- Matsukami, Hidenori
- Moschet, Christoph
- Oswald, Peter
- Plassmann, Merle
- Slobodnik, Jaroslav
- Yang, Chun
- Publisher
- Springer Nature
Abstract
Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GC×GC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants.
Subject
- Chemistry,
- Pollutants,
- Environmental protection
Rights
Pagination
1957–1977
Peer review
Yes
Open access level
Gold
Identifiers
- ISSN
-
1618-2650
- 1618-2642
Article
- Journal title
- Analytical and Bioanalytical Chemistry
- Journal volume
- 411
- Accepted date
- 2019-01-15
- Submitted date
- 2018-11-06