A systematic review of the evidence on the associations and safety of COVID-19 vaccination and post COVID-19 condition

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DOI

https://doi.org/10.1017/s0950268823001279

Language of the publication
English
Date
2023-08-18
Type
Article
Author(s)
  • Jennings, Sydney
  • Corrin, Tricia
  • Waddell, Lisa
Publisher
Cambridge University Press

Abstract

Post COVID-19 condition (PCC) refers to persistent or recurring symptoms (>8 weeks) occurring ≤12 weeks following acute COVID-19. The objective of this systematic review was to assess the evidence on the risk of PCC with vaccination before or after COVID-19 or after developing PCC, and the safety of vaccination among those already experiencing PCC. A search was conducted up to 13 December 2022 and standard systematic review methodology was followed. Thirty-one observational studies were included. There is moderate confidence that two doses of vaccine given pre-infection reduced the odds of PCC (pooled OR (pOR) 0.67, 95% CI 0.60–0.74, I2 = 59.9%), but low confidence that one dose may not reduce the odds (pOR 0.64, 95% CI 0.31#x2013;1.31, I2 = 99.2%), and the evidence is very uncertain about the effect of three doses (pOR 0.45, 95% CI 0.10#x2013;1.99, I2 = 30.9%). One of three studies suggested vaccination shortly after COVID-19 may offer additional protection from developing PCC compared to unvaccinated individuals, but this evidence was very uncertain. For those with PCC, vaccination was not associated with worsening PCC symptoms (10 studies) and appears safe (3 studies), but it is unclear if vaccination may change established PCC symptoms.

Subject

  • Health

Keywords

  • COVID-19,
  • long-COVID,
  • meta-analysis,
  • post COVID-19 condition,
  • systematic review,
  • SARS-CoV-2,
  • vaccine,
  • vaccination

Rights

Peer review

Yes

Identifiers

PubMed ID
37594232
ISSN
0950-2688
Other
PMC10540166

Article

Journal title
Epidemiology and Infection
Journal volume
151
Article number
e145

Citation(s)

Jennings, S., Corrin, T., & Waddell, L. (2023). A systematic review of the evidence on the associations and safety of COVID-19 vaccination and post COVID-19 condition. Epidemiology and infection, 151, e145. https://doi.org/10.1017/S0950268823001279

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Public health surveillance

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