Pathological characteristics of domestic pigs orally infected with the virus strain causing the first reported African swine fever outbreaks in Vietnam
- DOI
- Language of the publication
- English
- Date
- 2023-03-01
- Type
- Article
- Author(s)
- Nguyen, Thi Thu Huyen
- Nguyen, Van Tam
- Le, Phuong Nam
- Mai, Nguyen Tuan Anh
- Dong, Van Hieu
- Bui, Tran Anh Dao
- Nguyen, Thi Lan
- Ambagala, Aruna
- Le, Van Phan
- Publisher
- MDPI
Abstract
African swine fever (ASF) is currently Vietnam’s most economically significant swine disease. The first ASF outbreak in Vietnam was reported in February 2019. In this study, VNUA/HY/ASF1 strain isolated from the first ASF outbreak was used to infect 10 eight-week-old pigs orally with 103 HAD50 per animal. The pigs were observed daily for clinical signs, and whole blood samples were collected from each animal for viremia detection. Dead pigs were subjected to full post-mortem analyses. All 10 pigs displayed acute or subacute clinical signs and succumbed to the infection between 10 to 27 (19.8 ± 4.66) days post-inoculation (dpi). The onset of clinical signs started around 4–14 dpi. Viremia was observed in pigs from 6–16 dpi (11.2 ± 3.55). Enlarged, hyperemic, and hemorrhagic lymph nodes, enlarged spleen, pneumonia, and hydropericardium were observed at post-mortem examinations.
Description
This article belongs to the special issue "Emergence and Control of African Swine Fever."
Subject
- Health and safety,
- Science and technology
Keywords
- African swine fever,
- Peste porcine africaine,
- Virus de la peste porcine africaine,
- African swine fever virus,
- African and classical swine fever,
- ASF,
- CSF
Rights
Pagination
1-12
Peer review
Yes
Open access level
Gold
Identifiers
- ISSN
- 2076-0817
Article
- Journal title
- Pathogens
- Journal volume
- 12
- Journal issue
- 3
- Article number
- 393
- Accepted date
- 2023-02-24
- Submitted date
- 2022-12-15
Citation(s)
Nguyen, T. T. H., Nguyen, V. T., Le, P. N., Mai, N. T. A., Dong, V. H., Bui, T. A. D., Nguyen, T. L., Ambagala, A., & Le, V. P. (2023). Pathological characteristics of domestic pigs orally infected with the virus strain causing the first reported African swine fever outbreaks in Vietnam. Pathogens, 12(3), Article 393. https://doi.org/10.3390/pathogens12030393