Open Access Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
Open Access Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
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- creativework.keywords - en
- COVID-19 Testing
- COVID-19* / diagnosis
- COVID-19* / epidemiology
- Child
- Humans
- Pandemics
- SARS-CoV-2*
- Saliva
- dc.contributor.author
- Hua, Nadia
- Corsten, Martin
- Bello, Alexander
- Bhatt, Maala
- Milwid, Rachael
- Champredon, David
- Turgeon, Patricia
- Zemek, Roger
- Dawson, Laurent
- Mitsakakis, Nicholas
- Webster, Richard
- Caulley, Lisa
- Angel, Jonathan B.
- Bastien, Nathalie
- Poliquin, Guillaume
- Johnson-Obaseki, Stephanie
- dc.date.accessioned
- 2024-03-08T18:50:37Z
- dc.date.available
- 2024-03-08T18:50:37Z
- dc.date.issued
- 2022-11-08
- dc.description - en
- Accurate and timely testing for SARS-CoV-2 in the pediatric population is crucial to control the COVID-19 pandemic; saliva testing has been proposed as a less invasive alternative to nasopharyngeal swabs. We sought to compare the detection of SARS-CoV-2 using saliva versus nasopharyngeal swab in the pediatric population, and to determine the optimum time of testing for SARS-CoV-2 using saliva. Among 1580 paired nasopharyngeal and saliva tests, 60 paired samples were positive for SARS-CoV-2. Forty-four (73.3%) were concordant-positive results and 16 (26.6%) were discordant, among which 8 were positive only on nasopharyngeal swab and 8 were positive only on saliva testing. The sensitivity of saliva was 84.6% (95% confidence interval 71.9%–93.1%). Salivary testing for SARS-CoV-2 in the pediatric population is less invasive and shows similar detection of SARS-CoV-2 to nasopharyngeal swabs. It may therefore provide a feasible alternative for diagnosis of SARS-CoV-2 infection in children.
- dc.description.abstract - en
- BACKGROUND: Accurate and timely testing for SARS-CoV-2 in the pediatric population is crucial to control the COVID-19 pandemic; saliva testing has been proposed as a less invasive alternative to nasopharyngeal swabs. We sought to compare the detection of SARS-CoV-2 using saliva versus nasopharyngeal swab in the pediatric population, and to determine the optimum time of testing for SARS-CoV-2 using saliva. METHODS: We conducted a longitudinal diagnostic study in Ottawa, Canada, from Jan. 19 to Mar. 26, 2021. Children aged 3–17 years were eligible if they exhibited symptoms of COVID-19, had been identified as a high-risk or close contact to someone confirmed positive for SARS-CoV-2 or had travelled outside Canada in the previous 14 days. Participants provided both nasopharyngeal swab and saliva samples. Saliva was collected using a self-collection kit (DNA Genotek, OM-505) or a sponge-based kit (DNA Genotek, ORE-100) if they could not provide a saliva sample into a tube. RESULTS: Among 1580 paired nasopharyngeal and saliva tests, 60 paired samples were positive for SARS-CoV-2. Forty-four (73.3%) were concordant-positive results and 16 (26.6%) were discordant, among which 8 were positive only on nasopharyngeal swab and 8 were positive only on saliva testing. The sensitivity of saliva was 84.6% (95% confidence interval 71.9%–93.1%). INTERPRETATION: Salivary testing for SARS-CoV-2 in the pediatric population is less invasive and shows similar detection of SARS-CoV-2 to nasopharyngeal swabs. It may therefore provide a feasible alternative for diagnosis of SARS-CoV-2 infection in children.
- dc.identifier.citation
- Hua N, Corsten M, Bello A, et al. Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study. CMAJ open. 2022;10(4):E981-E987. doi:https://doi.org/10.9778/cmajo.20210279
- dc.identifier.doi
- https://doi.org/10.9778/cmajo.20210279
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2035
- dc.language.iso
- en
- dc.publisher
- CMA Impact Inc.
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Open Access Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- E981-E987
- local.article.journalissue
- 4
- local.article.journaltitle
- CMAJ Open
- local.article.journalvolume
- 10
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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