Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montreal, Canada
Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montreal, Canada
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Full item details
- creativework.keywords - en
- SARS-CoV-2
- Serology
- Cohort
- Pediatric
- Seroconversion
- Seroreversion
- dc.contributor.author
- Zinszer, Kate
- Charland, Katia
- Pierce, Laura
- Saucier, Adrien
- McKinnon, Britt
- Hamelin, Marie-Ève
- Cheriet, Islem
- Da Torre, Margot Barbosa
- Carbonneau, Julie
- Nguyen, Cat Tuong
- De Serres, Gaston
- Papenburg, Jesse
- Boivin, Guy
- Quach, Caroline
- dc.date.accepted
- 2023-03-17
- dc.date.accessioned
- 2024-01-02T19:26:44Z
- dc.date.available
- 2024-01-02T19:26:44Z
- dc.date.issued
- 2023
- dc.date.submitted
- 2022-10-26
- dc.description.abstract - en
- OBJECTIVES: To use serological testing to assess the pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies in children and adolescents in Montréal, Canada. DESIGN: This analysis is from a prospective cohort study of children aged 2-17 years (at baseline) that included blood spots for antibody detection. The serostatus of participants was determined by enzymelinked immunosorbent assays using the receptor-binding domain from the spike protein and the nucleocapsid protein as antigens. We estimated seroprevalence, seroconversion rates, and the likelihood of seroreversion at 6 months and 1 year. RESULTS: The baseline (October 2020 to April 2021) seroprevalence was 5.8% (95% confidence interval [CI] 4.8-7.1), which increased to 10.5% (May to September 2021) and 11.0% (November 2021 to March 2022) for the respective follow-ups (95% CI 8.6-12.7; 95% CI 8.8-13.5). The crude rate of seroconversion over the study period was 12.8 per 100 person-years (95% CI 11.0-14.7). The adjusted hazard rates of seroconversion by child characteristics showed higher rates in children who were female, whose parent identified as a racial or ethnic minority, and in households with incomes in the lowest tercile of our study population. The likelihood of remaining seropositive at 6 months was 68% (95% CI 60-77%) and dropped to 42% (95% CI 32-56%) at 1 year. CONCLUSION: Serological studies continue to provide valuable contributions for infection prevalence estimates and help us better understand the dynamics of antibody levels after infection.
- dc.identifier.doi
- https://doi.org/10.1016/j.ijid.2023.03.036
- dc.identifier.issn
- 1201-9712
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1377
- dc.language.iso
- en
- dc.publisher
- Elsevier
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montreal, Canada
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journaltitle
- International Journal of Infectious Diseases
- local.article.journalvolume
- 131
- local.pagination
- 119-126
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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