Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex

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dc.contributor.author
Tsang, Raymond S.W.
Deceuninck, Genevieve
Meilleur, Courtney
Zhou, Jianwei
Lefebvre, Brigitte
De Wals, Philippe
dc.date.accessioned
2025-03-14T19:35:54Z
dc.date.available
2025-03-14T19:35:54Z
dc.date.issued
2024-06
dc.description.abstract - en
<p>Objective<br> To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains.</p> <p>Methods<br> IMD cases and MenY strains from January 1, 2015 to August 11, 2023 were analyzed for clonal analysis and prediction of susceptibility to MenB vaccines. MenY strains of ST-23 CC from Quebec were analyzed with global MenY strains by core-genomic multi-locus sequence typing (cg-MLST).</p> <p>Results<br> Since 2015 the serogroup distribution of IMD in Quebec has shifted from predominantly MenB to mainly MenY, with most (80.9 %) of the latter belonging to ST-23 CC. The median age of MenY cases due to ST-23 CC were statistically younger than MenY cases due to non-ST-23 CC. MenY of ST-23 CC showed genetic diversity and the major genetic cluster were similar to the Swedish Y1 strain. The increase in invasive MenY disease in Quebec was due to a sub-clade of Lineage 23.1 which caused an elevated proportion of severe disease in young adults.</p> <p>Conclusion<br> The increase in invasive MenY disease in Quebec, Canada was driven by the expansion of a sub-clade of Lineage 23.1 in young adults. Currently available quadrivalent A,C,W,Y-conjugate meningococcal vaccines were predicted to provide protection against these strains.</p>
dc.identifier.doi
https://doi.org/10.1016/j.jinf.2024.106163
dc.identifier.issn
0163-4453
dc.identifier.pubmedID
38670267
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/3526
dc.language.iso
en
dc.publisher - en
Elsevier Ltd on behalf of The British Infection Association
dc.rights - en
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights - fr
Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
dc.rights.openaccesslevel - en
Gold
dc.rights.openaccesslevel - fr
Or
dc.rights.uri - en
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
dc.subject - en
Health
Epidemiology
Immunization
dc.subject - fr
Santé
Épidémiologie
Immunisation
dc.subject.en - en
Health
Epidemiology
Immunization
dc.subject.fr - fr
Santé
Épidémiologie
Immunisation
dc.title - en
Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex
dc.type - en
Article
dc.type - fr
Article
local.acceptedmanuscript.articlenum
106163
local.article.journalissue
6
local.article.journaltitle - en
Journal of Infection
local.article.journalvolume
88
local.pagination
1-8
local.peerreview - en
Yes
local.peerreview - fr
Oui
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