Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex
Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex
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- dc.contributor.author
- Tsang, Raymond S.W.
- Deceuninck, Genevieve
- Meilleur, Courtney
- Zhou, Jianwei
- Lefebvre, Brigitte
- De Wals, Philippe
- dc.date.accessioned
- 2025-03-14T19:35:54Z
- dc.date.available
- 2025-03-14T19:35:54Z
- dc.date.issued
- 2024-06
- dc.description.abstract - en
- <p>Objective<br> To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains.</p> <p>Methods<br> IMD cases and MenY strains from January 1, 2015 to August 11, 2023 were analyzed for clonal analysis and prediction of susceptibility to MenB vaccines. MenY strains of ST-23 CC from Quebec were analyzed with global MenY strains by core-genomic multi-locus sequence typing (cg-MLST).</p> <p>Results<br> Since 2015 the serogroup distribution of IMD in Quebec has shifted from predominantly MenB to mainly MenY, with most (80.9 %) of the latter belonging to ST-23 CC. The median age of MenY cases due to ST-23 CC were statistically younger than MenY cases due to non-ST-23 CC. MenY of ST-23 CC showed genetic diversity and the major genetic cluster were similar to the Swedish Y1 strain. The increase in invasive MenY disease in Quebec was due to a sub-clade of Lineage 23.1 which caused an elevated proportion of severe disease in young adults.</p> <p>Conclusion<br> The increase in invasive MenY disease in Quebec, Canada was driven by the expansion of a sub-clade of Lineage 23.1 in young adults. Currently available quadrivalent A,C,W,Y-conjugate meningococcal vaccines were predicted to provide protection against these strains.</p>
- dc.identifier.doi
- https://doi.org/10.1016/j.jinf.2024.106163
- dc.identifier.issn
- 0163-4453
- dc.identifier.pubmedID
- 38670267
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/3526
- dc.language.iso
- en
- dc.publisher - en
- Elsevier Ltd on behalf of The British Infection Association
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- Epidemiology
- Immunization
- dc.subject - fr
- Santé
- Épidémiologie
- Immunisation
- dc.subject.en - en
- Health
- Epidemiology
- Immunization
- dc.subject.fr - fr
- Santé
- Épidémiologie
- Immunisation
- dc.title - en
- Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 106163
- local.article.journalissue
- 6
- local.article.journaltitle - en
- Journal of Infection
- local.article.journalvolume
- 88
- local.pagination
- 1-8
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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