The association between air pollution and hospitalization for patients with systemic lupus erythematosus in Chile: A daily time series analysis
The association between air pollution and hospitalization for patients with systemic lupus erythematosus in Chile: A daily time series analysis
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- dc.contributor.author
- Cakmak, Sabit
- Blanco-Vidal, Claudia
- Lukina, Anna O.
- Dales, Robert
- dc.date.accessioned
- 2024-03-08T14:14:01Z
- dc.date.available
- 2024-03-08T14:14:01Z
- dc.date.issued
- 2020-11-13
- dc.description - en
- "Health Canada is responsible for the assessment and management of health risks to Canadians associated with exposure to air pollutants in the environment. In this study, Health Canada assessed the risk associated with air pollutants and Idiopathic interstitial lung diseases (IILDs). IILD, characterized by inflammation and thickening/scarring of the fluid filled interconnected spaces in the lung, can cause difficulty breathing, low oxygen in the blood or even death within a few years, but its association with air pollution is not well known. Using ambient air pollution (Ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide and particulate matter) and climate data from seven air monitoring stations distributed in the seven urban centres in Santiago, Chile, along with daily patient hospitalization data from 2001 to 2012, an association between ambient air pollution and daily hospital admissions for IILD was tested. Our findings suggest that short term increases in air pollution may be one risk factor in the worsening of IILD symptoms requiring hospitalization. Given that air pollution exposure is modifiable, findings from this study and those of others suggest that reducing exposure may possibly reduce hospitalizations for IILD. Exposure can be reduced through new cleaner methods of energy generation, and public education to reduce personal exposure."
- dc.description.abstract - en
- Genetic and environmental factors are thought to influence the activity of systemic lupus erythematosus (SLE), but relatively little is known about the effects of ambient air pollution. Using pollution data from air monitoring stations in the urban centers in Santiago Chile, along with daily patient hospitalization data from 2001 to 2012, an association between ambient air pollution and daily hospital admissions for SLE was tested using generalized linear models. Averaged over all regions pollutant mean 24 h concentrations were: 0.96 ppm carbon monoxide (CO), 64 ppb ozone (O3), 43 ppb nitrogen dioxide (NO2), 9 ppb sulphur dioxide (SO2), 29 μg/m3 particulate matter ≤ 2.5 μm in mean aerodynamic diameter (PM2.5), and 67 μg/m3 particulate matter ≤ 10 μm in diameter (PM10). The relative risk estimates in single pollutant models for an interquartile range (IQR) increase in pollutant were: RR = 1.34 (95% CI: 1.06–1.83) for SO2, RR = 1.60 (95% CI: 1.15–2.24) for CO, and RR = 1.41 (95% CI: 1.14–1.86) for PM2.5. In two-pollutant models, the significance of SO2 and PM2.5 persisted despite adjustments for each of the other measured pollutants. These findings suggest that acute increases in air pollution increase the risk of hospitalization with a primary diagnosis of SLE.
- dc.description.abstract-fosrctranslation - fr
- Genetic and environmental factors are thought to influence the activity of systemic lupus erythematosus (SLE), but relatively little is known about the effects of ambient air pollution. Using pollution data from air monitoring stations in the urban centers in Santiago Chile, along with daily patient hospitalization data from 2001 to 2012, an association between ambient air pollution and daily hospital admissions for SLE was tested using generalized linear models. Averaged over all regions pollutant mean 24 h concentrations were: 0.96 ppm carbon monoxide (CO), 64 ppb ozone (O3), 43 ppb nitrogen dioxide (NO2), 9 ppb sulphur dioxide (SO2), 29 μg/m3 particulate matter ≤ 2.5 μm in mean aerodynamic diameter (PM2.5), and 67 μg/m3 particulate matter ≤ 10 μm in diameter (PM10). The relative risk estimates in single pollutant models for an interquartile range (IQR) increase in pollutant were: RR = 1.34 (95% CI: 1.06–1.83) for SO2, RR = 1.60 (95% CI: 1.15–2.24) for CO, and RR = 1.41 (95% CI: 1.14–1.86) for PM2.5. In two-pollutant models, the significance of SO2 and PM2.5 persisted despite adjustments for each of the other measured pollutants. These findings suggest that acute increases in air pollution increase the risk of hospitalization with a primary diagnosis of SLE.
- dc.description.fosrctranslation - fr
- « Santé Canada est responsable de l'évaluation et de la gestion des risques pour la santé des Canadiens associés à l'exposition aux polluants atmosphériques présents dans l'environnement. Dans cette étude, Santé Canada a évalué le risque associé aux polluants atmosphériques et aux maladies pulmonaires interstitielles idiopathiques (MII). par l'inflammation et l'épaississement/la cicatrisation des espaces interconnectés remplis de liquide dans les poumons, peut provoquer des difficultés respiratoires, un faible taux d'oxygène dans le sang ou même la mort en quelques années, mais son association avec la pollution de l'air n'est pas bien connue. En utilisant la pollution de l'air ambiant (ozone, dioxyde d'azote, dioxyde de soufre, monoxyde de carbone et particules) et les données climatiques de sept stations de surveillance de l'air réparties dans les sept centres urbains de Santiago, au Chili, ainsi que les données quotidiennes d'hospitalisation des patients de 2001 à 2012, une L'association entre la pollution de l'air ambiant et les hospitalisations quotidiennes pour IILD a été testée. Nos résultats suggèrent que l'augmentation à court terme de la pollution atmosphérique pourrait être un facteur de risque d'aggravation des symptômes de l'IILD nécessitant une hospitalisation. Étant donné que l'exposition à la pollution atmosphérique est modifiable, les résultats de cette étude et ceux d'autres suggèrent que la réduction de l'exposition pourrait éventuellement réduire les hospitalisations pour IILD. L'exposition peut être réduite grâce à de nouvelles méthodes plus propres de production d'énergie et à l'éducation du public pour réduire l'exposition personnelle.
- dc.identifier.doi
- https://doi.org/10.1016/j.envres.2020.110469
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2023
- dc.language.iso
- en
- dc.publisher
- Elsevier
- dc.subject - en
- Health
- Health and safety
- dc.subject - fr
- Santé
- Santé et sécurité
- dc.subject.en - en
- Health
- Health and safety
- dc.subject.fr - fr
- Santé
- Santé et sécurité
- dc.title - en
- The association between air pollution and hospitalization for patients with systemic lupus erythematosus in Chile: A daily time series analysis
- dc.type - en
- Article
- dc.type - fr
- Article
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