Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

McClure, Kendra A.; Gong, YuiHui; Song, Jun; Vinqvist-Tymchuk, Melinda; Campbell Palmer, Leslie; Fan, Lihua; Burgher-MacLellan, Karen; Zhang, ZhaoQi; Celton, Jean-Marc; Forney, Charles F.; Migicovsky, Zoë; Myles, Sean

Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

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creativework.keywords - en: Apples--Breeding; Plant polyphenols; Pommier--Amélioration; Polyphénols végétaux
creativework.keywords - fr: Métabolisme secondaire; Metabolism, Secondary; Antioxydants; Antioxidants
dc.contributor.author: McClure, Kendra A.; Gong, YuiHui; Song, Jun; Vinqvist-Tymchuk, Melinda; Campbell Palmer, Leslie; Fan, Lihua; Burgher-MacLellan, Karen; Zhang, ZhaoQi; Celton, Jean-Marc; Forney, Charles F.; Migicovsky, Zoë; Myles, Sean
dc.date.accepted: 2019-07-24
dc.date.accessioned: 2024-10-18T18:24:23Z
dc.date.available: 2024-10-18T18:24:23Z
dc.date.issued: 2019-09-07
dc.date.submitted: 2019-05-03
dc.description.abstract - en: Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing, primarily as dietary antioxidants. Although numerous pre- and post-harvest factors can affect the composition of polyphenols in apples, genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple cultivars. Here we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography (HPLC) data with ~100,000 single nucleotide polymorphisms (SNPs) from two diverse apple populations. We found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars, and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic loci. Using GWAS, we identified candidate genes for the production of quercitrin, epicatechin, catechin, chlorogenic acid, 4-O-caffeoylquinic acid and procyanidins B1, B2, and C1. Our observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through marker-assisted breeding or gene editing.
dc.identifier.citation: McClure, K. A., Gong, Y., Song, J., Vinqvist-Tymchuk, M., Campbell Palmer, L., Fan, L., Burgher-MacLellan, K., Zhang, Z., Celton, J.-M., Forney, C. F., Migicovsky, Z., & Myles, S, (2019). Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols. Horticulture Research, 6, Article 107. https://doi.org/10.1038/s41438-019-0190-y
dc.identifier.doi: https://doi.org/10.1038/s41438-019-0190-y
dc.identifier.issn: 2052-7276
dc.identifier.uri: https://open-science.canada.ca/handle/123456789/3073
dc.language.iso: en
dc.publisher: Nature Publishing Group
dc.rights - en: Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights - fr: Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.openaccesslevel - en: Gold
dc.rights.openaccesslevel - fr: Or
dc.rights.uri - en: https://creativecommons.org/licenses/by/4.0/
dc.rights.uri - fr: https://creativecommons.org/licenses/by/4.0/deed.fr
dc.subject - en: Agriculture
dc.subject - fr: Agriculture
dc.subject.en - en: Agriculture
dc.subject.fr - fr: Agriculture
dc.title - en: Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols
dc.type - en: Article
dc.type - fr: Article
local.acceptedmanuscript.articlenum: 107
local.article.journaltitle: Horticulture Research
local.article.journalvolume: 6
local.pagination: 1-12
local.peerreview - en: Yes
local.peerreview - fr: Oui
local.requestdoi: No