Meta-analysis and structural dynamics of the emergence of genetic variants of SARS-CoV-2

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DOI

https://doi.org/10.3389/fmicb.2021.676314

Language of the publication
English
Date
2021-06-29
Type
Article
Author(s)
  • Castonguay, Nicolas
  • Zhang, Wandong
  • Langlois, Marc-André
Publisher
Frontiers Media S.A.

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late December 2019 in Wuhan, China, and is the causative agent for the worldwide COVID-19 pandemic. SARS-CoV-2 is a positive-sense single-stranded RNA virus belonging to the betacoronavirus genus. Due to the error-prone nature of the viral RNA-dependent polymerase complex, coronaviruses are known to acquire new mutations at each cycle of genome replication. This constitutes one of the main factors driving the evolution of its relatively large genome and the emergence of new genetic variants. In the past few months, the identification of new B.1.1.7 (United Kingdom), B.1.351 (South Africa), and P.1 (Brazil) variants of concern (VOC) has highlighted the importance of tracking the emergence of mutations in the SARS-CoV-2 genome that impact transmissibility, virulence, and immune and neutralizing antibody escape. Here we analyzed the appearance and prevalence trajectory over time of mutations that appeared in all SARS-CoV-2 genes from December 2019 to April 2021. The goal of the study was to identify which genetic modifications are the most frequent and study the dynamics of their propagation, their incorporation into the consensus sequence, and their impact on virus biology. We also analyzed the structural properties of the spike glycoprotein of the B.1.1.7, B.1.351, and P.1 variants for its binding to the host receptor ACE2. This study offers an integrative view of the emergence, disappearance, and consensus sequence integration of successful mutations that constitute new SARS-CoV-2 variants and their impact on neutralizing antibody therapeutics and vaccines.

Subject

  • Health,
  • Coronavirus diseases,
  • Coronaviruses

Rights

Pagination

1-19

Peer review

Yes

Identifiers

PubMed ID
34267735
ISSN
1664-302X

Article

Journal title
Frontiers in Microbiology
Journal volume
12
Article number
676314

Sponsors

This study was supported by a COVID-19 Rapid Response grant to M-AL by the Canadian Institute of Health Research (CIHR) and by a grant supplement by the Canadian Immunity Task Force (CITF).

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Collection(s)

Communicable diseases

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