Whole-genome comparisons of ergot fungi reveals the divergence and evolution of species within the genus Claviceps are the result of varying mechanisms driving genome evolution and host range expansion

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dc.contributor.author

Wyka, Stephen A.

Mondo, Stephen J.

Liu, Miao

Dettman, Jeremy

Nalam, Vamsi

Broders, Kirk D.

dc.date.accepted

2020-12-16

dc.date.accessioned

2024-07-30T20:43:14Z

dc.date.available

2024-07-30T20:43:14Z

dc.date.issued

2021-01-29

dc.description.abstract - en

The genus Claviceps has been known for centuries as an economically important fungal genus for pharmacology and agricultural research. Only recently have researchers begun to unravel the evolutionary history of the genus, with origins in South America and classification of four distinct sections through ecological, morphological, and metabolic features (Claviceps sects. Citrinae, Paspalorum, Pusillae, and Claviceps). The first three sections are additionally characterized by narrow host range, whereas section Claviceps is considered evolutionarily more successful and adaptable as it has the largest host range and biogeographical distribution. However, the reasons for this success and adaptability remain unclear. Our study elucidates factors influencing adaptability by sequencing and annotating 50 Claviceps genomes, representing 21 species, for a comprehensive comparison of genome architecture and plasticity in relation to host range potential. Our results show the trajectory from specialized genomes (sects. Citrinae and Paspalorum) toward adaptive genomes (sects. Pusillae and Claviceps) through colocalization of transposable elements around predicted effectors and a putative loss of repeat-induced point mutation resulting in unconstrained tandem gene duplication coinciding with increased host range potential and speciation. Alterations of genomic architecture and plasticity can substantially influence and shape the evolutionary trajectory of fungal pathogens and their adaptability. Furthermore, our study provides a large increase in available genomic resources to propel future studies of Claviceps in pharmacology and agricultural research, as well as, research into deeper understanding of the evolution of adaptable plant pathogens.

dc.identifier.citation

Wyka, S. A., Mondo, S. J., Liu, M., Dettman, J., Nalam, V., & Broders, K. D. (2021). Whole-genome comparisons of ergot fungi reveals the divergence and evolution of species within the genus Claviceps are the result of varying mechanisms driving genome evolution and host range expansion. Genome Biology and Evolution, 13(2). https://doi.org/10.1093/gbe/evaa267

dc.identifier.doi

https://doi.org/10.1093/gbe/evaa267

dc.identifier.issn

1759-6653

dc.identifier.uri

https://open-science.canada.ca/handle/123456789/2770

dc.language.iso

en

dc.publisher

Oxford University Press

dc.rights - en

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights - fr

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights.openaccesslevel - en

Gold

dc.rights.openaccesslevel - fr

Or

dc.rights.uri - en

https://creativecommons.org/licenses/by/4.0/

dc.rights.uri - fr

https://creativecommons.org/licenses/by/4.0/deed.fr

dc.subject - en

Agriculture

dc.subject - fr

Agriculture

dc.subject.en - en

Agriculture

dc.subject.fr - fr

Agriculture

dc.title - en

Whole-genome comparisons of ergot fungi reveals the divergence and evolution of species within the genus Claviceps are the result of varying mechanisms driving genome evolution and host range expansion

dc.type - en

Article

dc.type - fr

Article

local.acceptedmanuscript.articlenum

evaa267

local.article.journalissue

2

local.article.journaltitle

Genome Biology and Evolution

local.article.journalvolume

13

local.peerreview - en

Yes

local.peerreview - fr

Oui

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