Specific recruitment of phosphoinositide species to the plant-pathogen interfacial membrane underlies Arabidopsis susceptibility to fungal infection

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creativework.keywords - en

Arabidopsis thaliana

Arabidopsis thaliana

Fungi

Champignons

Host-parasite relationships

creativework.keywords - fr

Relations hôte-parasite

Plant diseases

Plantes--Maladies et fléaux

Phosphatidylinositol

Phosphatidylinositols

dc.contributor.author

Qin, Li

Zhou, Zhuqing

Li, Qiang

Zhai, Chun

Liu, Lijiang

Quilichini, Teagen D.

Gao, Peng

Kessler, Sharon A.

Jaillais, Yvon

Datla, Raju

Peng, Gary

Xiang, Daoquan

Wei, Yangdou

dc.date.accepted

2020-03-09

dc.date.accessioned

2024-06-03T15:25:40Z

dc.date.available

2024-06-03T15:25:40Z

dc.date.issued

2020-03-10

dc.date.submitted

2019-12-16

dc.description.abstract - en

Different phosphoinositides enriched at the membranes of specific subcellular compartments within plant cells contribute to organelle identity, ensuring appropriate cellular trafficking and function. During the infection of plant cells, biotrophic pathogens such as powdery mildews enter plant cells and differentiate into haustoria. Each haustorium is enveloped by an extrahaustorial membrane (EHM) derived from the host plasma membrane. Little is known about the EHM biogenesis and identity. Here, we demonstrate that among the two plasma membrane phosphoinositides in Arabidopsis (Arabidopsis thaliana), PI(4,5)P2 is dynamically up-regulated at powdery mildew infection sites and recruited to the EHM, whereas PI4P is absent in the EHM. Lateral transport of PI(4,5)P2 into the EHM occurs through a brefeldin A-insensitive but actin-dependent trafficking pathway. Furthermore, the lower levels of PI(4,5)P2 in pip5k1 pip5k2 mutants inhibit fungal pathogen development and cause disease resistance, independent of cell death-associated defenses and involving impaired host susceptibility. Our results reveal that plant biotrophic and hemibiotrophic pathogens modulate the subcellular distribution of host phosphoinositides and recruit PI(4,5)P2 as a susceptibility factor for plant disease.

dc.identifier.citation

Qin, L., Zhou, Z., Li, Q., Zhai, C., Liu, L., Quilichini, T. D., Gao, P., Kessler, S. A., Jaillais, Y., Datla, R., Peng, G., Xiang, D., & Wei, Y. (2020). Specific recruitment of phosphoinositide species to the plant-pathogen interfacial membrane underlies Arabidopsis susceptibility to fungal infection. Plant Cell, 32(5), 1665-1688. https://doi.org/10.1105/tpc.19.00970

dc.identifier.doi

https://doi.org/10.1105/tpc.19.00970

dc.identifier.issn

1040-4651

1532-298X

dc.identifier.uri

https://open-science.canada.ca/handle/123456789/2528

dc.language.iso

en

dc.publisher

American Society of Plant Biologists

dc.rights - en

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights - fr

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights.openaccesslevel - en

Gold

dc.rights.openaccesslevel - fr

Or

dc.rights.uri - en

https://creativecommons.org/licenses/by/4.0/

dc.rights.uri - fr

https://creativecommons.org/licenses/by/4.0/deed.fr

dc.subject - en

Nature and environment

dc.subject - fr

Nature et environnement

dc.subject.en - en

Nature and environment

dc.subject.fr - fr

Nature et environnement

dc.title - en

Specific recruitment of phosphoinositide species to the plant-pathogen interfacial membrane underlies Arabidopsis susceptibility to fungal infection

dc.type - en

Article

dc.type - fr

Article

local.article.journalissue

5

local.article.journaltitle

Plant Cell

local.article.journalvolume

32

local.pagination

1665-1688

local.peerreview - en

Yes

local.peerreview - fr

Oui

local.requestdoi

No

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