Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine

Tauzin, Alexandra; Nicolas, Alexandre; Ding, Shilei; Benlarbi, Mehdi; Medjahed, Halima; Chatterjee, Debashree; Dionne, Katrina; Gong, Shang Yu; Gendron-Lepage, Gabrielle; Bo, Yuxia; Perreault, Josée; Goyette, Guillaume; Gakool, Laurie; Arlotto, Pascale; Morrisseau, Chantal; Tremblay, Cécile; Martel-Laferrière, Valérie; De Serres, Gaston; Levade, Inès; Kaufmann, Daniel E.; Côté, Marceline; Bazin, Renée; Finzi, Andrés

Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine

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creativework.keywords - en: coronavirus; COVID-19; SARS-CoV-2; third mRNA vaccine dose; spike glycoproteins; B cell responses; humoral responses; neutralization; Omicron subvariants; hybrid immunity
dc.contributor.author: Tauzin, Alexandra; Nicolas, Alexandre; Ding, Shilei; Benlarbi, Mehdi; Medjahed, Halima; Chatterjee, Debashree; Dionne, Katrina; Gong, Shang Yu; Gendron-Lepage, Gabrielle; Bo, Yuxia; Perreault, Josée; Goyette, Guillaume; Gakool, Laurie; Arlotto, Pascale; Morrisseau, Chantal; Tremblay, Cécile; Martel-Laferrière, Valérie; De Serres, Gaston; Levade, Inès; Kaufmann, Daniel E.; Côté, Marceline; Bazin, Renée; Finzi, Andrés
dc.date.accessioned: 2024-01-12T21:39:39Z
dc.date.available: 2024-01-12T21:39:39Z
dc.date.issued: 2023-01-31
dc.description - en: Tauzin et al. report that while the third dose of mRNA vaccine induces poor humoral responses against new Omicron subvariants in naive people, better responses are observed in individuals with hybrid immunity. They also observe that BA.4/5 and BQ.1.1 are less recognized and neutralized than other Omicron subvariants.
dc.description.abstract - en: HIGHLIGHTS •In naive donors, the boost induces poor humoral responses against Omicron variants •Hybrid immunity generates better humoral responses than vaccination alone •BA.4/5 and BQ.1.1 spikes are more resistant than other Omicron subvariants SUMMARY Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have recently emerged, becoming the dominant circulating strains in many countries. These variants contain a large number of mutations in their spike glycoprotein, raising concerns about vaccine efficacy. In this study, we evaluate the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to recognize and neutralize these Omicron subvariant spikes. We observed that BA.4/5 and BQ.1.1 spikes are markedly less recognized and neutralized compared with the D614G and other Omicron subvariant spikes tested. Also, individuals who have been infected before or after vaccination present better humoral responses than SARS-CoV-2-naive vaccinated individuals, thus indicating that hybrid immunity generates better humoral responses against these subvariants.
dc.identifier.citation: Tauzin A, Nicolas A, Ding S, et al. Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine. Cell Reports. 2023;42(1):111998-111998. doi:https://doi.org/10.1016/j.celrep.2023.111998
dc.identifier.doi: https://doi.org/10.1016/j.celrep.2023.111998
dc.identifier.uri: https://open-science.canada.ca/handle/123456789/1770
dc.language.iso: en
dc.publisher: Cell Press
dc.rights - en: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights - fr: Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
dc.rights.openaccesslevel - en: Gold
dc.rights.openaccesslevel - fr: Or
dc.rights.uri - en: https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri - fr: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
dc.subject - en: Health
dc.subject - fr: Santé
dc.subject.en - en: Health
dc.subject.fr - fr: Santé
dc.title - en: Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine
dc.type - en: Article
dc.type - fr: Article
local.acceptedmanuscript.articlenum: 111998
local.article.journalissue: 1
local.article.journaltitle: Cell Reports
local.article.journalvolume: 42
local.peerreview - en: Yes
local.peerreview - fr: Oui