The burden of incidental SARS-CoV-2 infections in hospitalized patients across pandemic waves in Canada
The burden of incidental SARS-CoV-2 infections in hospitalized patients across pandemic waves in Canada
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- dc.contributor.author
- McAlister, Finlay A.
- Hau, Jeffrey P.
- Atzema, Clare
- McRae, Andrew D.
- Morrison, Laurie J.
- Grant, Lars
- Cheng, Ivy
- Rosychuk, Rhonda J.
- Hohl, Corinna M.
- Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) Investigators
- dc.date.accessioned
- 2025-02-14T16:50:24Z
- dc.date.available
- 2025-02-14T16:50:24Z
- dc.date.issued
- 2023-04-24
- dc.description.abstract - en
- Many health authorities differentiate hospitalizations in patients infected with SARS-CoV-2 as being "for COVID-19" (due to direct manifestations of SARS-CoV-2 infection) versus being an "incidental" finding in someone admitted for an unrelated condition. We conducted a retrospective cohort study of all SARS-CoV-2 infected patients hospitalized via 47 Canadian emergency departments, March 2020-July 2022 to determine whether hospitalizations with "incidental" SARS-CoV-2 infection are less of a burden to patients and the healthcare system. Using a priori standardized definitions applied to hospital discharge diagnoses in 14,290 patients, we characterized COVID-19 as (i) the "Direct" cause for the hospitalization (70%), (ii) a potential "Contributing" factor for the hospitalization (4%), or (iii) an "Incidental" finding that did not influence the need for admission (26%). The proportion of incidental SARS-CoV-2 infections rose from 10% in Wave 1 to 41% during the Omicron wave. Patients with COVID-19 as the direct cause of hospitalization exhibited significantly longer LOS (mean 13.8 versus 12.1 days), were more likely to require critical care (22% versus 11%), receive COVID-19-specific therapies (55% versus 19%), and die (17% versus 9%) compared to patients with Incidental SARS-CoV-2 infections. However, patients hospitalized with incidental SARS-CoV-2 infection still exhibited substantial morbidity/mortality and hospital resource use.
- dc.identifier.doi
- https://doi.org/10.1038/s41598-023-33569-2
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/3447
- dc.language.iso
- en
- dc.publisher - en
- Nature Portfolio
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- Coronavirus diseases
- dc.subject - fr
- Santé
- Maladie à coronavirus
- dc.subject.en - en
- Health
- Coronavirus diseases
- dc.subject.fr - fr
- Santé
- Maladie à coronavirus
- dc.title - en
- The burden of incidental SARS-CoV-2 infections in hospitalized patients across pandemic waves in Canada
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 6635
- local.article.journalissue
- 1
- local.article.journaltitle - en
- Scientific Reports
- local.article.journalvolume
- 13
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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