SARS-CoV-2 (COVID-19) serology: implications for clinical practice, laboratory medicine and public health

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dc.contributor.author
Van Caeseele, Paul
Bailey, Dana
Forgie, Sarah E.
Dingle, Tanis C.
Krajden, Mel
dc.date.accessioned
2024-01-11T15:27:12Z
dc.date.available
2024-01-11T15:27:12Z
dc.date.issued
2020-08-24
dc.description.abstract - en
KEY POINTS Multiple commercial assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been approved for use as serological tests by Health Canada, with some manufacturers claiming about 95% sensitivity and about 99.5% specificity. The detectable presence of SARS-CoV-2 antibodies has not yet been proven to confer meaningful or durable immunity to reinfection. Thus, serological testing should not be used to guide individual decisions about personal or occupational exposures, use of personal protective equipment and physical distancing. At present, clinical indications for serologic testing in health care settings are limited, and SARS-CoV-2 serological testing has no role in routine clinical care. Serological testing at this time should be focused on research concerning immunity to SARS-CoV-2 and population-level studies to inform public health responses to the Canadian coronavirus disease 2019 (COVID-19) epidemic.
dc.description.fosrcfull - en
Reuse of Articles Published Prior to January 1, 2021: Single copies of articles published prior to January 1, 2021 may only be copied or shared for non-commercial educational purposes. Appropriate credits must be given. The distribution of derivative works is not permitted. Please email permissions@cma.ca to obtain consent for any other uses. https://www.cmaj.ca/copyright
dc.identifier.citation
Van Caeseele P, Bailey D, Forgie SE, Dingle TC, Krajden M. SARS-CoV-2 (COVID-19) serology: implications for clinical practice, laboratory medicine and public health. CMAJ : Canadian Medical Association Journal. 2020;192(34):E973-E979. doi:https://doi.org/10.1503/cmaj.201588
dc.identifier.doi
https://doi.org/10.1503/cmaj.201588
dc.identifier.issn
0820-3946
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/1701
dc.language.iso
en
dc.publisher
CMAJ Group
dc.rights - en
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights - fr
Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
dc.rights.openaccesslevel - en
Not Applicable
dc.rights.openaccesslevel - fr
Pas applicable
dc.rights.uri - en
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
dc.subject - en
Health
dc.subject - fr
Santé
dc.subject.en - en
Health
dc.subject.fr - fr
Santé
dc.title - en
SARS-CoV-2 (COVID-19) serology: implications for clinical practice, laboratory medicine and public health
dc.type - en
Article
dc.type - fr
Article
local.article.journalissue
34
local.article.journaltitle
Canadian Medical Association Journal
local.article.journalvolume
192
local.pagination
E973-E979
local.peerreview - en
Yes
local.peerreview - fr
Oui
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