The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers
The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers
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- creativework.keywords - en
- COVID-19
- prospective studies
- reinfection
- SARS-CoV-2
- serology
- dc.contributor.author
- Racine, Étienne
- Boivin, Guy
- Longtin, Yves
- McCormack, Deirdre
- Decaluwe, Hélène
- Savard, Patrice
- Cheng, Matthew P.
- Hamelin, Marie-Ève
- Carbonneau, Julie
- Tadount, Fazia
- Adams, Kelsey
- Bourdin, Benoîte
- Nantel, Sabryna
- Gilca, Vladimir
- Corbeil, Jacques
- De Serres, Gaston
- Quach-Thanh, Caroline
- dc.date.accessioned
- 2024-01-29T15:18:53Z
- dc.date.available
- 2024-01-29T15:18:53Z
- dc.date.issued
- 2022-05-05
- dc.description.abstract - en
- BACKGROUND: Understanding the immune response to natural infection by SARS-CoV-2 is key to pandemic management, especially in the current context of emerging variants. Uncertainty remains regarding the efficacy and duration of natural immunity against reinfection. METHODS: We conducted an observational prospective cohort study in Canadian healthcare workers (HCWs) with a history of PCR-confirmed SARS-CoV-2 infection to (i) measure the average incidence rate of reinfection and (ii) describe the serological immune response to the primary infection. RESULTS: Our cohort comprised 569 HCWs; median duration of individual follow-up was 371 days. We detected six cases of reinfection in absence of vaccination between August 21, 2020, and March 1, 2022, for a reinfection incidence rate of 4.0 per 100 person-years. Median duration of seropositivity was 415 days in symptomatics at primary infection compared with 213 days in asymptomatics (p < 0.0001). Other characteristics associated with prolonged seropositivity for IgG against the spike protein included age over 55 years, obesity, and non-Caucasian ethnicity. CONCLUSIONS: Among unvaccinated healthcare workers, reinfection with SARS-CoV-2 following a primary infection remained rare.
- dc.description.sponsorship
- Fonds de recherche du Québec - Santé; Public Health Agency of Canada; Canadian Institutes of Health Research, Grant/Award Number: VR2-172712
- dc.identifier.doi
- https://doi.org/10.1111/irv.12997
- dc.identifier.issn
- 1750-2640
- dc.identifier.pubmedID
- 35510653
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1898
- dc.language.iso
- en
- dc.publisher
- John Wiley & Sons Ltd.
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journalissue
- 5
- local.article.journaltitle
- Influenza and Other Respiratory Viruses
- local.article.journalvolume
- 16
- local.pagination
- 916-925
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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