Higher contact among vaccinated can be a mechanism for negative vaccine effectiveness
- DOI
- Language of the publication
- English
- Date
- 2022-05-13
- Type
- Submitted manuscript
- Author(s)
- Bodner, Korryn
- Knight, Jesse
- Hamilton, Mackenzie A.
- Mishra, Sharmistha
- Publisher
- medRxiv
Abstract
Evidence from early observational studies suggested negative vaccine effectiveness for the SARS-CoV-2 Omicron variant. Using transmission modeling, we illustrated how increased contact between vaccinated individuals, vaccinated contact heterogeneity, paired with lower vaccine efficacies could produce negative measurements and how we can identify this mechanism via a key temporal signature.
Subject
- Health,
- Coronavirus diseases,
- Immunization,
- Modelling
Rights
Pagination
1-9
Peer review
No
Open access level
Green
Sponsors
This study was funded by the Canada COVID-19 Immunity Task Force grant