Detection of a reassortant swine- and human-origin H3N2 Influenza A virus in farmed mink in British Columbia, Canada

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creativework.keywords - en
Avian influenza
Genomics
American mink--Diseases
Influenza A virus
Zoonoses
creativework.keywords - fr
Grippe aviaire
Génomique
Vison d'Amérique--Maladies
Influenzavirus A
Zoonoses
dc.contributor.author
Kuchinski, Kevin S.
Tyson, John
Lee, Tracy
Detmer, Susan
Berhane, Yohannes
Burns, Theresa
Prystajecky, Natalie A.
Himsworth, Chelsea G.
dc.date.accepted
2024-12-14
dc.date.accessioned
2025-04-08T12:59:55Z
dc.date.available
2025-04-08T12:59:55Z
dc.date.issued
2024-12-29
dc.date.submitted
2024-07-11
dc.description.abstract - en
Introduction In December 2021, influenza A viruses (IAV) were detected in a population of farmed mink in British Columbia, Canada. Circulation of IAVs in farmed mink populations has raised public health concerns due to similarities between mustelid and human respiratory physiology, potentially facilitating spillover of zoonotic influenzas from livestock. Methods Oropharyngeal specimens were collected from mink as part of a surveillance program for SARS-CoV-2. Diagnostic RT-qPCR testing was performed using a multiplex assay targeting SARS-CoV-2, IAV, influenza B virus and respiratory syncytial virus. Whole viral genome sequencing was conducted on IAV-positive specimens, followed by phylogenetic analysis with other animal and human IAV genome sequences from large global databases. Results IAVs were detected in 17 of 65 mink by RT-qPCR. Based on genomic sequencing and phylogenetic analysis, these IAVs were subtyped as H3N2s that originated from reassortment of swine H3N2 (clade 1990.4 h), human seasonal H1N1 (pdm09) and swine H1N2 (clade 1A.1.1.3). This reassortant has been subsequently observed in swine in several Midwest American states, as well as in swine and turkeys in Ontario, suggesting its spillover into farmed mink in British Columbia was incidental to its broader dissemination in North American swine populations. Conclusions These detections reaffirm the need for extensive genomic surveillance of IAVs in swine populations to monitor reassortments that might become public health concerns. They also highlight the need for closer surveillance of IAVs in mink to preserve animal health, protect agricultural interests, and monitor potential zoonotic threats.
dc.description.fosrcfull - en
Published online in 2024. Published in print in 2025.
dc.description.fosrcfull-fosrctranslation - fr
Publié en ligne en 2024. Publié en version imprimée en 2025.
dc.identifier.citation
Kuchinski, K. S., Tyson, J., Lee, T., Detmer, S., Berhane, Y., Burns, T., Prystajecky, N. A., & Himsworth, C. G. (2025). Detection of a reassortant swine- and human-origin H3N2 Influenza A virus in farmed mink in British Columbia, Canada. Zoonoses and Public Health, 72(3), 293-300. https://doi.org/10.1111/zph.13205
dc.identifier.doi
https://doi.org/10.1111/zph.13205
dc.identifier.issn
1863-2378
1863-1959
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/3581
dc.language.iso
en
dc.publisher - en
Wiley
dc.publisher - fr
Wiley
dc.rights - en
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights - fr
Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
dc.rights.openaccesslevel - en
Gold
dc.rights.openaccesslevel - fr
Or
dc.rights.uri - en
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
dc.subject - en
Animal diseases
Viruses
dc.subject - fr
Maladie animale
Virus
dc.subject.en - en
Animal diseases
Viruses
dc.subject.fr - fr
Maladie animale
Virus
dc.title - en
Detection of a reassortant swine- and human-origin H3N2 Influenza A virus in farmed mink in British Columbia, Canada
dc.type - en
Article
dc.type - fr
Article
local.article.journalissue
3
local.article.journaltitle - en
Zoonoses and Public Health
local.article.journalvolume
72
local.pagination
293-300
local.peerreview - en
Yes
local.peerreview - fr
Oui
local.requestdoi
No
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