Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals
- DOI
- Language of the publication
- English
- Date
- 2024-07-23
- Type
- Article
- Author(s)
- Erdelyan, Cassidy N.G.
- Kandeil, Ahmed
- Signore, Anthony V.
- Jones, Megan E.B.
- Vogel, Peter
- Andreev, Konstantin
- Bøe, Cathrine Arnason
- Gjerset, Britt
- Alkie, Tamiru N.
- Yason, Carmencita
- Hisanaga, Tamiko
- Sullivan, Daniel
- Lung, Oliver
- Bourque, Laura
- Ayilara, Ifeoluwa
- Pama, Lemarie
- Jeevan, Trushar
- Franks, John
- Jones, Jeremy C.
- Seiler, Jon P.
- Miller, Lance
- Mubareka, Samira
- Webby, Richard J.
- Berhane, Yohannes
- Publisher
- Elsevier B.V.
Abstract
Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into North America was detected, followed shortly thereafter by a mammalian detection. As these A(H5N5) viruses were similar to contemporary viruses described in Eurasia, the transatlantic spread of A(H5N5) viruses was most likely facilitated by pelagic seabirds. Some of the Canadian A(H5N5) viruses from birds and mammals possessed the PB2-E627K substitution known to facilitate adaptation to mammals. Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission. However, these viruses have maintained receptor binding traits of avian influenza viruses and were susceptible to oseltamivir and zanamivir. Understanding the factors influencing the virulence and transmission of A(H5N5) in migratory birds and mammals is critical to minimize impacts on wildlife and public health.
Subject
- Influenza,
- Animal diseases,
- Viruses
Keywords
- Avian influenza
Rights
Peer review
Yes
Open access level
Gold
Identifiers
- ISSN
- 2211-1247
Article
- Journal title
- Cell Reports
- Journal volume
- 43
- Journal issue
- 7
- Article number
- 114479
- Accepted date
- 2024-06-25
- Submitted date
- 2024-04-15
Citation(s)
Erdelyan, C. N. G., Kandeil, A., Signore, A. V., Jones, M. E. B., Vogel, P., Andreev, K., Bøe, C. A., Gjerset, B., Alkie, T. N., Yason, C., Hisanaga, T., Sullivan, D., Lung, O., Bourque, L., Ayilara, I., Pama, L., Jeevan, T., Franks, J., Jones, J. C., … Berhane, Y. (2024). Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4B A(H5N5) virus into North America and spillover to mammals. Cell Reports, 43(7), 114479. https://doi.org/10.1016/j.celrep.2024.114479