Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus)

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creativework.keywords - en

Transmissible spongiform encephalitis

Transmissible spongiform encephalopathies

Prion disease

creativework.keywords - fr

Encéphalopathie spongiforme transmissible

Encéphalopathies spongiformes transmissibles

Maladies à prions

dc.contributor.author

Mitchell, Gordon B.

Sigurdson, Christina J.

O’Rourke, Katherine I.

Algire, James

Harrington, Noel P.

Walther, Ines

Spraker, Terry R.

Balachandran, Aru

Kincaid, Anthony E.

dc.date.accepted

2012-05-15

dc.date.accessioned

2026-02-25T18:08:59Z

dc.date.available

2026-02-25T18:08:59Z

dc.date.issued

2012-06-18

dc.date.submitted

2012-05-04

dc.description.abstract - en

Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, remains prevalent in North American elk, white-tailed deer and mule deer. A natural case of CWD in reindeer (Rangifer tarandus tarandus) has not been reported despite potential habitat overlap with CWD-infected deer or elk herds. This study investigates the experimental transmission of CWD from elk or white-tailed deer to reindeer by the oral route of inoculation. Ante-mortem testing of the three reindeer exposed to CWD from white-tailed deer identified the accumulation of pathological PrP (PrP(CWD)) in the recto-anal mucosa associated lymphoid tissue (RAMALT) of two reindeer at 13.4 months post-inoculation. Terminal CWD occurred in the two RAMALT-positive reindeer at 18.5 and 20 months post-inoculation while one other reindeer in the white-tailed deer CWD inoculum group and none of the 3 reindeer exposed to elk CWD developed disease. Tissue distribution analysis of PrP(CWD) in CWD-affected reindeer revealed widespread deposition in central and peripheral nervous systems, lymphoreticular tissues, the gastrointestinal tract, neuroendocrine tissues and cardiac muscle. Analysis of prion protein gene (PRNP) sequences in the 6 reindeer identified polymorphisms at residues 2 (V/M), 129 (G/S), 138 (S/N) and 169 (V/M). These findings demonstrate that (i) a sub-population of reindeer are susceptible to CWD by oral inoculation implicating the potential for transmission to other Rangifer species, and (ii) certain reindeer PRNP polymorphisms may be protective against CWD infection.

dc.identifier.citation

Mitchell, G. B., Sigurdson, C. J., O’Rourke, K. I., Algire, J., Harrington, N. P., Walther, I., Spraker, T. R., & Balachandran, A. (2012). Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS ONE, 7(6). https://doi.org/10.1371/journal.pone.0039055

dc.identifier.doi

https://doi.org/10.1371/journal.pone.0039055

dc.identifier.issn

1932-6203

dc.identifier.uri

https://open-science.canada.ca/handle/123456789/4255

dc.language.iso

en

dc.publisher - en

Public Library of Science (PLoS)

dc.publisher - fr

Public Library of Science (PLoS)

dc.rights - en

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights - fr

Creative Commons Attribution 4.0 International (CC BY 4.0)

dc.rights.uri - en

https://creativecommons.org/licenses/by/4.0/

dc.rights.uri - fr

https://creativecommons.org/licenses/by/4.0/deed.fr

dc.subject - en

Animal diseases

dc.subject - fr

Maladie animale

dc.subject.en - en

Animal diseases

dc.subject.fr - fr

Maladie animale

dc.title - en

Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus)

dc.type - en

Article

dc.type - fr

Article

local.article.journalissue

6

local.article.journaltitle - en

PLOS One

local.article.journalvolume

7

local.peerreview - en

Yes

local.peerreview - fr

Oui

local.requestdoi - en

No

local.requestdoi - fr

No

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