Detection of anticoagulant rodenticides by direct analysis in real time time-of-flight mass spectrometry : novel screening techniques and rapid semi-quantitative determination
Detection of anticoagulant rodenticides by direct analysis in real time time-of-flight mass spectrometry : novel screening techniques and rapid semi-quantitative determination
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Full item details
- dc.contributor.author
- Yu, Trista
- Moorthy, Arun S.
- Brunswick, Pamela
- Rosary, Bianca
- Cody, Robert
- Gian, Marcus
- Dang, Vanessa
- Kwok, Honoria
- Yan, Jeffrey
- Shang, Dayue
- dc.date.accepted
- 2025-10-12
- dc.date.accessioned
- 2026-02-10T14:17:56Z
- dc.date.available
- 2026-02-10T14:17:56Z
- dc.date.issued
- 2025-10-23
- dc.date.submitted
- 2025-08-29
- dc.description.abstract - en
- Environmental monitoring of rodenticide contamination is often required to address public concern of off-target poisoning, which threatens animal populations and disrupts related ecology. This study aimed to address the shortcomings of current analytical methods for testing water-soluble anticoagulant rodenticide by application of direct analysis in real time in tandem with time-of-flight (DART-ToF) mass spectrometry (MS), an alternative analytical technique offering rapidity, low cost, and robustness. Both positive and negative ion modes were investigated with the aim of establishing a quick screening and semi-quantitation workflow. Screening was conducted by development of a custom DART-ToF MS library with selected rodenticide spectra, and data was analyzed using the National Institute of Standards and Technology/National Institute of Justice DART-MS Data Interpretation Tool (NIST/NIJ DART-MS DIT). The developed methodology readily identified five rodenticides from complex mixtures at 1 mg L<sup>−1</sup> and one rodenticide at 10 mg L<sup>−1</sup>. Semi-quantitation was conducted through the internal standard method and negative mode ionization, with linear relationships from R2 = 0.98 to 0.99. While further optimization with alternative internal standards may be considered, this study revealed the analytical potential in DART-ToF for rapid identification and quantitation of many environmental contaminants.
- dc.identifier.doi
- https://doi.org/10.1039/D5AY01447F
- dc.identifier.issn
- 1759-9679
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/4230
- dc.language.iso
- en
- dc.publisher - en
- Royal Society of Chemistry
- dc.publisher - fr
- Royal Society of Chemistry
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Rodenticides
- Environmental management
- Detection
- Poisoning
- dc.subject - fr
- Rodenticide
- Gestion de l'environnement
- Détection
- Empoisonnement
- dc.subject.en - en
- Rodenticides
- Environmental management
- Detection
- Poisoning
- dc.subject.fr - fr
- Rodenticide
- Gestion de l'environnement
- Détection
- Empoisonnement
- dc.title - en
- Detection of anticoagulant rodenticides by direct analysis in real time time-of-flight mass spectrometry : novel screening techniques and rapid semi-quantitative determination
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journalissue
- 44
- local.article.journaltitle - en
- Analytical Methods
- local.article.journalvolume
- 17
- local.pagination
- 9000-9016
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
- local.requestdoi - en
- No
- local.requestdoi - fr
- No
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