Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers : a prospective cohort study

Cherry, Nicola; Adisesh, Anil; Burstyn, Igor; Charlton, Carmen; Chen, Yan; Durand-Moreau, Quentin; Labrèche, France; Ruzycki, Shannon; Turnbull, LeeAnn; Zadunayski, Tanis; Yasui, Yutaka

Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers : a prospective cohort study

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dc.contributor.author: Cherry, Nicola; Adisesh, Anil; Burstyn, Igor; Charlton, Carmen; Chen, Yan; Durand-Moreau, Quentin; Labrèche, France; Ruzycki, Shannon; Turnbull, LeeAnn; Zadunayski, Tanis; Yasui, Yutaka
dc.date.accessioned: 2024-12-18T19:22:14Z
dc.date.available: 2024-12-18T19:22:14Z
dc.date.issued: 2023-09-13
dc.description.abstract - en: Introduction Healthcare workers (HCWs) from an interprovincial Canadian cohort were asked to give serial blood samples to identify factors associated with anti-receptor binding domain (anti-RBD) IgG response to the SARS-CoV-2 virus. Methods Members of the HCW cohort donated blood samples four months after their first SARS-CoV-2 immunization and again at 7, 10 and 13 months. Date and type of immunizations and dates of SARS-CoV-2 infection were collected at each of four contacts, together with information on immunologically-compromising conditions and current therapies. Blood samples were analyzed centrally for anti-RBD IgG and anti-nucleocapsid IgG (Abbott Architect, Abbott Diagnostics). Records of immunization and SARS-CoV-2 testing from public health agencies were used to assess the impact of reporting errors on estimates from the random-effects multivariable model fitted to the data. Results 2752 of 4567 vaccinated cohort participants agreed to donate at least one blood sample. Modelling of anti-RBD IgG titer from 8903 samples showed an increase in IgG with each vaccine dose and with first infection. A decrease in IgG titer was found with the number of months since vaccination or infection, with the sharpest decline after the third dose. An immunization regime that included mRNA1273 (Moderna) resulted in higher anti-RBD IgG. Participants reporting multiple sclerosis, rheumatoid arthritis or taking selective immunosuppressants, tumor necrosis factor inhibitors, calcineurin inhibitors and antineoplastic agents had lower anti-RBD IgG. Supplementary analyses showed higher anti-RBD IgG in those reporting side-effects of vaccination, no relation of anti-RBD IgG to obesity and lower titers in women immunized early in pregnancy. Sensitivity analysis results suggested no important bias in the self-report data. Conclusion Creation of a prospective cohort was central to the credibility of results presented here. Serial serology assessments, with longitudinal analysis, provided effect estimates with enhanced accuracy and a clearer understanding of medical and other factors affecting response to vaccination.
dc.description.sponsorship: The College of Physicians and Surgeons of Alberta gave seed funding for the establishment of the HCW cohort. Grant funding was obtained from the Canadian Institutes of Health Research (Funding Reference number 173209). This funding was extended by a grant from the Canadian Immunology Task Force.
dc.identifier.doi: https://doi.org/10.1101/2023.09.12.23295445
dc.identifier.uri: https://open-science.canada.ca/handle/123456789/3225
dc.language.iso: en
dc.publisher - en: medRxiv
dc.rights - en: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights - fr: Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
dc.rights.uri - en: https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri - fr: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
dc.subject - en: Health; Coronavirus diseases
dc.subject - fr: Santé; Maladie à coronavirus
dc.subject.en - en: Health; Coronavirus diseases
dc.subject.fr - fr: Santé; Maladie à coronavirus
dc.title - en: Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers : a prospective cohort study
dc.type - en: Article
dc.type - fr: Article
local.pagination: 1-27
local.peerreview - en: No
local.peerreview - fr: Non