Single-nucleotide polymorphisms in ABC drug transporters alter expression and circulating tenofovir in healthy South African women exposed to pre-exposure prophylaxis
Single-nucleotide polymorphisms in ABC drug transporters alter expression and circulating tenofovir in healthy South African women exposed to pre-exposure prophylaxis
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Full item details
- creativework.keywords - en
- African women
- ATP-binding cassette drug transporters
- HIV
- pre-exposure prophylaxis
- single-nucleotide polymorphisms
- South Africa
- tenofovir
- Truvada®
- dc.contributor.author
- Zondo, Nomusa M.
- Sobia, Parveen
- Sivro, Aida
- Ngcapu, Sinaye
- Mansoor, Leila E.
- Mahomed, Sharana
- Lewis, Lara
- Ramsuran, Veron
- Archary, Derseree
- dc.date.accessioned
- 2023-10-18T15:08:47Z
- dc.date.available
- 2023-10-18T15:08:47Z
- dc.date.issued
- 2023-07-28
- dc.description.abstract - en
- AIM: We investigated if single-nucleotide polymorphisms (SNPs) in ATP-binding cassette (ABC) drug transporters alter gene expression and tenofovir disposition in South African women taking Truvada® for HIV prevention. MATERIALS & METHODS: In 393 women, real-time PCR was used to determine the associations between six SNPs in ABC transporter genes, mRNA expression and circulating-tenofovir. RESULTS: Univariable and multivariable analyses showed that CT and TT relative to CC genotypes for the ABCC4(3463C/T) SNP had significantly higher tenofovir levels. In contrast, the AA genotype for the ABCC4(4976A/G) SNP showed significantly less tenofovir, while mRNA expression was increased. CONCLUSION: SNPs in the ABCC4 gene may differentially affect gene expression and circulating tenofovir. Their impact may inform on low pre-exposure prophylaxis efficacy and discern effective drugs in clinical trials of African women enriched for certain genotypes.
- dc.identifier.citation
- Zondo, N. M., Sobia, P., Sivro, A., Ngcapu, S., Mansoor, L. E., Mahomed, S., Lewis, L., Ramsuran, V., & Archary, D. (2023). Single-nucleotide polymorphisms in ABC drug transporters alter expression and circulating tenofovir in healthy South African women exposed to pre-exposure prophylaxis. Pharmacogenomics, 24(11), 599–613. https://doi.org/10.2217/pgs-2023-0058
- dc.identifier.doi
- https://doi.org/10.2217/pgs-2023-0058
- dc.identifier.issn
- 1744-8042
- dc.identifier.pubmedID
- 37503696
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1223
- dc.language.iso
- en
- dc.publisher
- Future Medicine, an imprint of Future Science Group
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Single-nucleotide polymorphisms in ABC drug transporters alter expression and circulating tenofovir in healthy South African women exposed to pre-exposure prophylaxis
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journalissue
- 11
- local.article.journaltitle
- Pharmacogenomics
- local.article.journalvolume
- 24
- local.pagination
- 599–613
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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