Experimental oral transmission of chronic wasting disease to sika deer (Cervus nippon)

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creativework.keywords - en
Transmissible spongiform encephalopathies
Chronic wasting disease
Sika deer--Diseases
Communicable diseases--Transmission
Maladies infectieuses--Transmission
creativework.keywords - fr
Encéphalopathies spongiformes transmissibles
Maladie du dépérissement chronique
Cerf sika--Maladies
dc.contributor.author
Sohn, Hyun-Joo
Mitchell, Gordon
Lee, Yoon Hee
Kim, Hyo Jin
Park, Kyung-Je
Staskevicus, Antanas
Walther, Ines
Soutyrine, Andrei
Balachandran, Aru
dc.date.accepted
2020-11-23
dc.date.accessioned
2025-04-08T14:17:44Z
dc.date.available
2025-04-08T14:17:44Z
dc.date.issued
2020-12-10
dc.date.submitted
2020-06-29
dc.description.abstract - en
Chronic wasting disease (CWD) affects a broad array of cervid species and continues to be detected in an expanding geographic range. Initially introduced into the Republic of Korea through the importation of CWD-infected elk (Cervus canadensis), additional cases of CWD were subsequently detected in farmed Korean elk and sika deer (Cervus nippon). Wild and farmed sika deer are found in many regions of Asia, North America, and Europe, although natural transmission to this species has not been detected outside of the Republic of Korea. In this study, the oral transmission of CWD to sika deer was investigated using material from CWD-affected elk. Pathological prion (PrPCWD) immunoreactivity was detected in oropharyngeal lymphoid tissues of one sika deer at 3.9 months post-inoculation (mpi) and was more widely distributed in a second sika deer examined at 10.9 mpi. The remaining four sika deer progressed to clinical disease between 21 and 24 mpi. Analysis of PrPCWD tissue distribution in clinical sika deer revealed widespread deposition in central and peripheral nervous systems, lymphoreticular tissues, and the gastrointestinal tract. Prion protein gene (PRNP) sequences of these sika deer were identical and consistent with those reported in natural sika deer populations. These findings demonstrate the efficient oral transmission of CWD from elk to sika deer.
dc.identifier.citation
Sohn, H.-J., Mitchell, G., Lee, Y. H., Kim, H. J., Park, K.-J., Staskevicus, A., Walther, I., Soutyrine, A., & Balachandran, A. (2020). Experimental oral transmission of chronic wasting disease to sika deer (Cervus nippon). Prion, 14(1), 271–277. https://doi.org/10.1080/19336896.2020.1857038
dc.identifier.doi
https://doi.org/10.1080/19336896.2020.1857038
dc.identifier.issn
1933-690X
1933-6896
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/3585
dc.language.iso
en
dc.publisher - en
Taylor & Francis
dc.publisher - fr
Taylor & Francis
dc.rights - en
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights - fr
Creative Commons Attribution-Pas d’Utilisation Commerciale 4.0 International (CC BY-NC 4.0)
dc.rights.uri - en
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by-nc/4.0/deed.fr
dc.subject - en
Animal diseases
dc.subject - fr
Maladie animale
dc.subject.en - en
Animal diseases
dc.subject.fr - fr
Maladie animale
dc.title - en
Experimental oral transmission of chronic wasting disease to sika deer (Cervus nippon)
dc.type - en
Article
dc.type - fr
Article
local.article.journalissue
1
local.article.journaltitle - en
Prion
local.article.journalvolume
14
local.pagination
271-277
local.peerreview - en
Yes
local.peerreview - fr
Oui
local.requestdoi
No
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