Field evaluations of four SARS-CoV-2 rapid antigen tests during SARS-CoV-2 Delta variant wave in South Africa
Field evaluations of four SARS-CoV-2 rapid antigen tests during SARS-CoV-2 Delta variant wave in South Africa
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Full item details
- creativework.keywords - en
- Antigen rapid diagnostic test
- COVID-19
- Performance evaluation
- SARS-CoV-2
- dc.contributor.author
- Samsunder, Natasha
- Lustig, Gila
- Ngubane, Slindile
- Maseko, Thando Glory
- Rambaran, Santhuri
- Ngcapu, Sinaye
- Magini, Stanley Nzuzo
- Lewis, Lara
- Cawood, Cherie
- Kharsany, Ayesha B. M.
- Karim, Quarraisha Abdool
- Karim, Salim Abdool
- Naidoo, Kogieleum
- Sivro, Aida
- dc.date.accessioned
- 2023-10-03T21:37:41Z
- dc.date.available
- 2023-10-03T21:37:41Z
- dc.date.issued
- 2023-07-25
- dc.description.abstract - en
- <p> <b>Background</b>: Rapid antigen tests detecting SARS-CoV-2 were shown to be a useful tool in managing the COVID-19 pandemic. Here, we report on the results of a prospective diagnostic accuracy study of four SARS-CoV-2 rapid antigen tests in a South African setting. </p> <p> <b> Methods</b>: Rapid antigen test evaluations were performed through drive-through testing centres in Durban, South Africa, from July to December 2021. Two evaluation studies were performed: nasal Panbio COVID-19 Ag Rapid Test Device (Abbott) was evaluated in parallel with the nasopharyngeal Espline SARS-CoV-2 Ag test (Fujirebio), followed by the evaluation of nasal RightSign COVID-19 Antigen Rapid test Cassette (Hangzhou Biotest Biotech) in parallel with the nasopharyngeal STANDARD Q COVID-19 Ag test (SD Biosensor). The Abbott RealTime SARS-CoV-2 assay was used as a reference test. </p> <p> <b>Results</b>: Evaluation of Panbio and Espline Ag tests was performed on 494 samples (31% positivity), while the evaluation of Standard Q and RightTest Ag tests was performed on 539 samples (13.17% positivity). The overall sensitivity for all four tests ranged between 60 and 72% with excellent specificity values (> 98%). Sensitivity increased to > 80% in all tests in samples with cycle number value < 20. All four tests performed best in samples from patients presenting within the first week of symptom onset. </p> <p> <b>Conclusions</b>: All four evaluated tests detected a majority of the cases within the first week of symptom onset with high viral load. </p>
- dc.identifier.citation
- Samsunder, N., Lustig, G., Ngubane, S., Maseko, T. G., Rambaran, S., Ngcapu, S., Magini, S. N., Lewis, L., Cawood, C., Kharsany, A. B. M., Karim, Q. A., Karim, S. A., Naidoo, K., & Sivro, A. (2023). Field evaluations of four SARS-CoV-2 rapid antigen tests during SARS-CoV-2 Delta variant wave in South Africa. Diagnostic and prognostic research, 7(1), 14. https://doi.org/10.1186/s41512-023-00151-3
- dc.identifier.doi
- https://doi.org/10.1186/s41512-023-00151-3
- dc.identifier.issn
- 2397-7523
- dc.identifier.other
- PMC10369830
- dc.identifier.pubmedID
- 37491317
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1192
- dc.language.iso
- en
- dc.publisher
- BioMed Central
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Field evaluations of four SARS-CoV-2 rapid antigen tests during SARS-CoV-2 Delta variant wave in South Africa
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 14
- local.article.journalissue
- 1
- local.article.journaltitle
- Diagnostic and Prognostic Research
- local.article.journalvolume
- 7
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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