Toxicity assessment of exposure to four short- and ultra-short PFAS using Daphnia magna and Hydra vulgaris as models

Hanana, Houda; Houédé, Marie; Farley, Geneviève; Bouchard, Pascale; Sorel, Roxane; Dinh, Quoc Tuc; Sauvé, Sébastien; Houde, Magali

Toxicity assessment of exposure to four short- and ultra-short PFAS using Daphnia magna and Hydra vulgaris as models

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dc.contributor.author: Hanana, Houda; Houédé, Marie; Farley, Geneviève; Bouchard, Pascale; Sorel, Roxane; Dinh, Quoc Tuc; Sauvé, Sébastien; Houde, Magali
dc.date.accessioned: 2025-11-25T15:14:13Z
dc.date.available: 2025-11-25T15:14:13Z
dc.date.issued: 2025-10-24
dc.description.abstract - en: Short- and ultra-short per- and polyfluoroalkyl substances (PFAS) such as perfluorobutanoic acid (PFBA, 4C), perfluorobutane sulfonic acid (PFBS, 4C), trifluoroacetic acid (TFA, 2C) and trifluoromethane sulfonic acid (TFMS, 1C) were detected in various environmental matrices but studies addressing the effects attributed to exposure are still scarce. This study aimed to (1) investigate acute toxicity of these emerging PFAS using Daphnia magna (immobility, mortality, reproduction, and body size) and Hydra vulgaris (morphological changes and reproduction) and (2) assess the sub-chronic/chronic toxicity of TFA in both species. Glutathione S-transferase (GST) activity was also assessed in both species after long-term exposure to TFA. Chemical analysis confirmed presence and stability of 4 PFAS in exposure media. For all tested PFAS, endpoints examined after acute tests were not markedly affected by exposure and LC50 values were > 1000 mg/L. However, this toxicity was significantly affected by media acidification induced by the tested chemicals (LC50 = 316 and 31,6 mg/L for D. magna and H. vulgaris, respectively). Long-term exposure to TFA did not significantly induce any effect on both species and GST levels were not altered. Overall, results suggest lower toxicity of ultra/short-chain PFAS to these species under selected exposure conditions. However, additional studies investigating multigenerational effects of these PFAS using realistic environmental concentrations are needed to overcome the significant gaps in our understanding of short /ultra-short PFAS-induced toxicity.
dc.description.fosrcfull - en: This is an original manuscript of an article published by Taylor & Francis in Journal of Toxicology and Environmental Health, Part A on 24 October 2025, available at: <a href="https://doi.org/10.1080/15287394.2025.2570788">https://doi.org/10.1080/15287394.2025.2570788</a>.
dc.description.fosrcfull-fosrctranslation - fr: Ceci est un manuscrit soumis d'un article publié par Taylor & Francis dans Journal of Toxicology and Environmental Health, Part A le 24 octobre 2025, disponible à : <a href="https://doi.org/10.1080/15287394.2025.2570788">https://doi.org/10.1080/15287394.2025.2570788</a>.
dc.identifier.issn: 1528-7394; 1087-2620
dc.identifier.uri: https://open-science.canada.ca/handle/123456789/4042
dc.language.iso: en
dc.publisher - en: Taylor & Francis
dc.publisher - fr: Taylor & Francis
dc.relation.isreplacedby: https://doi.org/10.1080/15287394.2025.2570788
dc.rights - en: Open Government Licence - Canada
dc.rights - fr: Licence du gouvernement ouvert - Canada
dc.rights.openaccesslevel - en: Green
dc.rights.openaccesslevel - fr: Vert
dc.rights.uri - en: https://open.canada.ca/en/open-government-licence-canada
dc.rights.uri - fr: https://ouvert.canada.ca/fr/licence-du-gouvernement-ouvert-canada
dc.subject - en: Crustaceans; Pollutants
dc.subject - fr: Crustacé; Polluant
dc.subject.en - en: Crustaceans; Pollutants
dc.subject.fr - fr: Crustacé; Polluant
dc.title - en: Toxicity assessment of exposure to four short- and ultra-short PFAS using Daphnia magna and Hydra vulgaris as models
dc.type - en: Submitted manuscript
dc.type - fr: Manuscrit soumis
local.article.journaltitle - en: Journal of Toxicology and Environmental Health, Part A
local.pagination: 29 pages, annexes
local.peerreview - en: No
local.peerreview - fr: Non
local.requestdoi - en: No
local.requestdoi - fr: No

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