Molecular and pathological characterization of classical swine fever virus genotype 2 strains responsible for the 2013–2018 outbreak in colombia

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DOI

https://doi.org/10.3390/v15122308

Language of the publication
English
Date
2023-11-24
Type
Article
Author(s)
  • Robert, Erin
  • Goonewardene, Kalhari
  • Lamboo, Lindsey
  • Perez, Orlando
  • Goolia, Melissa
  • Lewis, Charles
  • Erdelyan, Cassidy N. G.
  • Lung, Oliver
  • Handel, Katherine
  • Moffat, Estella
  • Embury-Hyatt, Carissa
  • Amaya, Nancy Naranjo
  • Parra, Claudia Patricia Calderón
  • Rueda, Diana Cristina Gómez
  • Monroy, Maria Antonia Rincón
  • Clavijo, Alfonso
  • Ambagala, Aruna
Publisher
MDPI

Abstract

Classical swine fever (CSF) is a highly contagious transboundary viral disease of domestic and wild pigs. Despite mass vaccination and continuous eradication programs, CSF remains endemic in Asia, some countries in Europe, the Caribbean and South America. Since June 2013, Northern Colombia has reported 137 CSF outbreaks, mostly in backyard production systems with low vaccination coverage. The purpose of this study was to characterize the virus responsible for the outbreak. Phylogenetic analysis based on the full-length E2 sequence shows that the virus is closely related to CSF virus (CSFV) genotype 2.6 strains circulating in Southeast Asia. The pathotyping experiment suggests that the virus responsible is a moderately virulent strain. The 190 nucleotide stretch of the E2 hypervariable region of these isolates also shows high similarity to the CSFV isolates from Colombia in 2005 and 2006, suggesting a common origin for the CSF outbreaks caused by genotype 2.6 strains. The emergence of genotype 2.6 in Colombia suggests a potential transboundary spread of CSFV from Asia to the Americas, complicating the ongoing CSF eradication efforts in the Americas, and emphasizes the need for continuous surveillance in the region.

Subject

  • Animal diseases

Keywords

  • Classical swine fever,
  • African and classical swine fever,
  • ASF,
  • CSF

Rights

Peer review

Yes

Article

Journal title
Viruses
Journal volume
15
Journal issue
12
Accepted date
2023-11-16
Submitted date
2023-09-01

Citation(s)

Robert, E., Goonewardene, K., Lamboo, L., Perez, O., Goolia, M., Lewis, C., Erdelyan, C. N. G., Lung, O., Handel, K., Moffat, E., Embury-Hyatt, C., Amaya, N. N., Parra, C. P. C., Rueda, D. C. G., Monroy, M. A. R., Clavijo, A., & Ambagala, A. (2023, November 24). Molecular and pathological characterization of classical swine fever virus genotype 2 strains responsible for the 2013–2018 outbreak in Colombia. MDPI. https://doi.org/10.3390/v15122308

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