Risk of COVID-19 hospitalization in people living with HIV and HIV-negative individuals and the role of COVID-19 vaccination: a retrospective cohort study
Risk of COVID-19 hospitalization in people living with HIV and HIV-negative individuals and the role of COVID-19 vaccination: a retrospective cohort study
Simple item page
Full item details
- dc.contributor.author
- Puyat, Joseph H.
- Fowokan, Adeleke
- Wilton, James
- Janjua, Naveed Z.
- Wong, Jason
- Grennan, Troy
- Chambers, Catharine
- Kroch, Abigail
- Costiniuk, Cecilia T.
- Cooper, Curtis L.
- Lauscher, Darren
- Strong, Monte
- Burchell, Ann N.
- Anis, Aslam H.
- Samji, Hasina
- COVAXHIV Study Team
- dc.date.accessioned
- 2024-07-05T14:16:54Z
- dc.date.available
- 2024-07-05T14:16:54Z
- dc.date.issued
- 2023-10
- dc.description.abstract - en
- OBJECTIVE: To examine the risk of hospitalization within 14 days of COVID-19 diagnosis among people living with HIV (PLWH) and HIV-negative individuals who had laboratory-confirmed SARS-CoV-2 infection. METHODS: We used Cox proportional hazard models to compare the relative risk of hospitalization in PLWH and HIV-negative individuals. Then, we used propensity score weighting to examine the influence of sociodemographic factors and comorbid conditions on risk of hospitalization. These models were further stratified by vaccination status and pandemic period (pre-Omicron: December 15, 2020, to November 21, 2021; Omicron: November 22, 2021, to October 31, 2022). RESULTS: The crude hazard ratio (HR) for risk of hospitalization in PLWH was 2.44 (95% confidence interval [CI]: 2.04-2.94). In propensity score-weighted models that included all covariates, the relative risk of hospitalization was substantially attenuated in the overall analyses (adjusted HR [aHR]: 1.03; 95% CI: 0.85-1.25), in vaccinated (aHR 1.00; 95% CI: 0.69-1.45), inadequately vaccinated (aHR: 1.04; 95% CI: 0.76-1.41) and unvaccinated individuals (aHR: 1.15; 95% CI: 0.84-1.56). CONCLUSION: PLWH had about two times the risk of COVID-19 hospitalization than HIV-negative individuals in crude analyses which attenuated in propensity score-weighted models. This suggests that the risk differential can be explained by sociodemographic factors and history of comorbidity, underscoring the need to address social and comorbid vulnerabilities (e.g., injecting drugs) that were more prominent among PLWH.
- dc.identifier.doi
- https://doi.org/10.1016/j.ijid.2023.06.026
- dc.identifier.issn
- 1201-9712
- dc.identifier.pubmedID
- 37419410
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2652
- dc.language.iso
- en
- dc.publisher
- International Society for Infectious Diseases
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Risk of COVID-19 hospitalization in people living with HIV and HIV-negative individuals and the role of COVID-19 vaccination: a retrospective cohort study
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journaltitle
- International Journal of Infectious Diseases
- local.article.journalvolume
- 135
- local.pagination
- 49-56
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
Download(s)
Original bundle
1 - 1 of 1
Name: puyat-risk-of-covid-19-hospitalization-people-living-with-hiv-and-hiv-negative.pdf
Size: 1.01 MB
Format: PDF
Collection(s)