Structure elucidation of catechins for modulation of starch digestion
Structure elucidation of catechins for modulation of starch digestion
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Full item details
- creativework.keywords - en
- Catechin
- Amylases--Inhibitors
- Starch
- Digestion
- creativework.keywords - fr
- Catéchine
- Amylases--Inhibiteurs
- Amidon
- Digestion
- dc.contributor.author
- Miao, Ming
- Jiang, Huan
- Jiang, Bo
- Li, Yungao
- Cui, Steve W.
- Zhang, Tao
- dc.date.accepted
- 2014-01-08
- dc.date.accessioned
- 2026-01-30T13:54:47Z
- dc.date.available
- 2026-01-30T13:54:47Z
- dc.date.issued
- 2014-01-15
- dc.date.submitted
- 2013-07-09
- dc.description.abstract - en
- This study investigated interactions of six type catechins monomers with human pancreatic α-amylase and the structural requirements for inhibitory activity. The in vitro and in silico results showed that inhibitory effects of catechins followed the order: (+)-gallocatechin-3-O-gallate > (−)-epicatechin-3-O-gallate > (−)-epigallocatechin-3-O-gallate > (−)-epicatechin > (−)-epigallocatechin > (+)-catechin. The A, B and C rings of catechins affected the activity by interact with the catalytic residues of the active site of α-amylase forming a phenols–protein complex, including hydroxyl on the 3-position or 5-position of A–C rings, number of hydroxyl substation on the B-ring or C ring, or 2,3-cis/trans isomerism. The galloylated catechins has higher binding affinity with α-amylase than non-galloylated catechins. The results showed that biological activity of catechins against α-amylase, which supported catechins monomer is a promising ingredient as a development strategy of health food for regulation of energy balance and reduction of related diseases risk.
- dc.identifier.citation
- Miao, M., Jiang, H., Jiang, B., Li, Y., Cui, S. W., & Zhang, T. (2014). Structure elucidation of catechins for modulation of starch digestion. LWT - Food Science and Technology, 57(1), 188-193. https://doi.org/10.1016/j.lwt.2014.01.005
- dc.identifier.doi
- https://doi.org/10.1016/j.lwt.2014.01.005
- dc.identifier.issn
- 1096-1127
- 0023-6438
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/4174
- dc.language.iso
- en
- dc.publisher - en
- Elsevier
- dc.publisher - fr
- Elsevier
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Food
- Physiology
- dc.subject - fr
- Aliment
- Physiologie
- dc.subject.en - en
- Food
- Physiology
- dc.subject.fr - fr
- Aliment
- Physiologie
- dc.title - en
- Structure elucidation of catechins for modulation of starch digestion
- dc.type - en
- Article
- dc.type - fr
- Article
- local.article.journalissue
- 1
- local.article.journaltitle - en
- LWT - Food Science and Technology
- local.article.journalvolume
- 57
- local.pagination
- 188-193
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
- local.requestdoi - en
- No
- local.requestdoi - fr
- No
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