Clarifying winter clean heating importance : insight chemical compositions and cytotoxicity exposure to primary and aged pollution emissions in China rural areas
Clarifying winter clean heating importance : insight chemical compositions and cytotoxicity exposure to primary and aged pollution emissions in China rural areas
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Full item details
- dc.contributor.author
- Sun, Jian
- Niu, Xinyi
- Zhang, Bin
- Zhang, Leiming
- Yu, Jinjin
- He, Kun
- Zhang, Tian
- Wang, Qiyuan
- Xu, Hongmei
- Cao, Junji
- Shen, Zhenxing
- dc.date.accepted
- 2022-07-19
- dc.date.accessioned
- 2024-04-17T18:34:40Z
- dc.date.available
- 2024-04-17T18:34:40Z
- dc.date.issued
- 2022-10-15
- dc.date.submitted
- 2022-05-13
- dc.description.abstract - en
- Residential solid fuel combustion (RSFC) is an important source of PM<sub>2.5</sub>. Here we investigate the cytotoxicity of primarily emitted and photochemically aged PM<sub>2.5</sub> to A549 cells. Owing to the formation of water-soluble ions and organics (e.g., oPAHs and nPAHs), emission factors of PM<sub>2.5</sub> were increased by 44.4% on average after 7-day equivalent photochemical aging, which greatly altered chemical profiles of freshly emitted PM<sub>2.5</sub>. Consequently, the cytotoxicity varied with aging duration that 2-day and 7-day aged PM<sub>2.5</sub> induced 22.5% and 35.1%, respectively, higher levels of reactive oxygen species than primary emissions. Similar increases were also observed for multi-cytotoxicity. Correlation analysis and western blot results collectively confirmed HO-1/Nrf-2 signaling pathway dominated the cytotoxicity of aged PM<sub>2.5</sub> from RSFC, which was regulated by the enhanced o-PAHs and n-PAHs during photochemical aging. Thus, aged and secondary aerosol exposure needs to be paid more attention due to the enhanced cytotoxicity and the vast crowd involved.
- dc.identifier.issn
- 1095-8630
- 0301-4797
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/2341
- dc.language.iso
- en
- dc.publisher
- Elsevier
- dc.relation.isreplacedby
- https://doi.org/10.1016/j.jenvman.2022.115822
- https://open-science.canada.ca/handle/123456789/3174
- dc.rights - en
- Open Government Licence - Canada
- dc.rights - fr
- Licence du gouvernement ouvert - Canada
- dc.rights.openaccesslevel - en
- Green
- dc.rights.openaccesslevel - fr
- Vert
- dc.rights.uri - en
- https://open.canada.ca/en/open-government-licence-canada
- dc.rights.uri - fr
- https://ouvert.canada.ca/fr/licence-du-gouvernement-ouvert-canada
- dc.subject - en
- Nature and environment
- Science and technology
- dc.subject - fr
- Nature et environnement
- Sciences et technologie
- dc.subject.en - en
- Nature and environment
- Science and technology
- dc.subject.fr - fr
- Nature et environnement
- Sciences et technologie
- dc.title - en
- Clarifying winter clean heating importance : insight chemical compositions and cytotoxicity exposure to primary and aged pollution emissions in China rural areas
- dc.type - en
- Submitted manuscript
- dc.type - fr
- Manuscrit soumis
- local.acceptedmanuscript.articlenum
- 115822
- local.article.journaltitle
- Journal of Environmental Management
- local.article.journalvolume
- 320
- local.pagination
- 40 pages
- local.peerreview - en
- No
- local.peerreview - fr
- Non
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