Injectable antimicrobials in commercial feedlot cattle and their effect on the nasopharyngeal microbiota and antimicrobial resistance

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dc.contributor.author
Holman, Devin B.
Timsit, Edouard
Booker, Calvin W.
Alexander, Trevor W.
dc.date.accessioned
2023-04-13T20:55:53Z
dc.date.available
2023-04-13T20:55:53Z
dc.date.issued
2018-01-03
dc.description.abstract - en
Beef cattle in North America that are deemed to be at high risk of developing bovine respiratory disease (BRD) are frequently administered a metaphylactic antibiotic injection to control the disease. Cattle may also receive in-feed antimicrobials to prevent specific diseases and ionophores to improve growth and feed efficiency. Presently, attempts to evaluate the effects that these medications have on antibiotic resistance in the bovine nasopharyngeal microbiota have been focused on culturable bacteria that are associated with BRD. Therefore, we assessed the effects of injectable antibiotics on the nasopharyngeal microbiota of commercial feedlot cattle in Alberta, Canada, through the first 60 d on feed. Although all cattle in the study were also receiving in-feed chlortetracycline and monensin, the administration of a single injection of either oxytetracycline or tula- thromycin at feedlot placement altered the nasopharyngeal microbiota in comparison with the cattle receiving only in-feed antibiotics. Oxytetracycline significantly (P < 0.05) reduced the relative abundance of Mannheimia spp. from feedlot entry to exit (≥60 d) and both oxytetracycline and tulathromycin treated cattle had a sig- nificantly lower relative abundance of Mycoplasma spp. at feedlot exit compared with the in-feed antibiotic only group. The proportion of the tetracycline resistance gene tet(H) was significantly increased following oxyte- tracycline injection (P < 0.05). Oxytetracycline also reduced both the number of OTUs and the Shannon di- versity index in the nasopharyngeal microbiota (P < 0.05). These results demonstrate that in feedlot cattle receiving subtherapeutic in-feed antimicrobials, the administration of a single injection of either oxytetracycline or tulathromycin resulted in measurable changes to the nasopharyngeal microbiota during the first 60 d fol- lowing feedlot placement
dc.identifier.citation
Holman, D. B., Timsit, E., Booker, C. W., &; Alexander, T. W. (2018). Injectable antimicrobials in commercial feedlot cattle and their effect on the nasopharyngeal microbiota and antimicrobial resistance. Veterinary Microbiology, 214, 140–147. https://doi.org/10.1016/j.vetmic.2017.12.015
dc.identifier.doi
https://doi.org/10.1016/j.vetmic.2017.12.015
dc.identifier.issn
1873-2542
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/164
dc.language.iso
en
dc.publisher
Elsevier
dc.rights.openaccesslevel - en
Green
dc.rights.openaccesslevel - fr
Vert
dc.subject - en
Agriculture
dc.subject - fr
Agriculture
dc.subject.en - en
Agriculture
dc.subject.fr - fr
Agriculture
dc.title - en
Injectable antimicrobials in commercial feedlot cattle and their effect on the nasopharyngeal microbiota and antimicrobial resistance
dc.title.fosrctranslation - fr
Injectable antimicrobials in commercial feedlot cattle and their effect on the nasopharyngeal microbiota and antimicrobial resistance
dc.type - en
Article
dc.type - fr
Article
local.article.journaltitle
Veterinary Microbiology
local.article.journalvolume
214
local.article.pagination
140-147
local.peerreview - en
Yes
local.peerreview - fr
Oui
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