Lingonberry improves non-alcoholic fatty liver disease by reducing hepatic lipid accumulation, oxidative stress and inflammatory response
Lingonberry improves non-alcoholic fatty liver disease by reducing hepatic lipid accumulation, oxidative stress and inflammatory response
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- creativework.keywords - en
- Berries
- Non-alcoholic Fatty Liver Disease
- Oxidative Stress
- Diet, High-Fat
- Lipids
- Glutathione
- Inflammation
- creativework.keywords - fr
- Baies (Fruits)
- Stéatose hépatique non alcoolique
- Stress oxydatif
- Régimes riches en gras et en sucres
- Lipides
- Glutathion
- Inflammation (Pathologie)
- dc.contributor.author
- Madduma Hewage, Susara
- Prashar, Suvira
- O, Karmin.
- Siow, Yaw L.
- dc.date.accepted
- 2021-04-01
- dc.date.accessioned
- 2026-01-30T15:45:19Z
- dc.date.available
- 2026-01-30T15:45:19Z
- dc.date.issued
- 2021-04-05
- dc.date.submitted
- 2021-02-28
- dc.description.abstract - en
- Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally and there is a pressing need for effective treatment. Lipotoxicity and oxidative stress are the important mediators in NAFLD pathogenesis. Lingonberry (Vaccinium vitis-idaea L.) is rich in anthocyanins that have antioxidant and anti-inflammatory properties. The present study investigated the effect of lingonberry supplementation on liver injury in C57BL/6J male mice fed a high-fat diet (HFD) for 12 weeks. Mice fed HFD displayed liver injury with steatosis, increased lipid peroxidation and inflammatory cytokine expression in the liver as compared to mice fed a control diet. Lingonberry supplementation for 12 weeks alleviated HFD-induced liver injury, attenuated hepatic lipid accumulation, and inflammatory cytokine expression. Lingonberry supplementation inhibited the expression of sterol regulatory element-binding protein-1c (SREBP-1c) and acetyl-CoA carboxylase-1 (AAC-1) as well as activated AMP-activated protein kinase (AMPK) in the liver. It also decreased HFD-induced hepatic oxidative stress and aggregation of inflammatory foci. This was associated with a restoration of nuclear factor erythroid 2–related factor 2 (Nrf2) and glutathione level in the liver. These results suggest that lingonberry supplementation can protect against HFD-induced liver injury partly through attenuation of hepatic lipid accumulation, oxidative stress, and inflammatory response.
- dc.identifier.citation
- Madduma Hewage, S., Prashar, S., O, K., & Siow, Y. L. (2021). Lingonberry improves non-alcoholic fatty liver disease by reducing hepatic lipid accumulation, oxidative stress and inflammatory response. Antioxidants, 10(4), Article 565. https://doi.org/10.3390/antiox10040565
- dc.identifier.doi
- https://doi.org/10.3390/antiox10040565
- dc.identifier.issn
- 2076-3921
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/4176
- dc.language.iso
- en
- dc.publisher - en
- MDPI
- dc.publisher - fr
- MDPI
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Fruits
- Diseases
- dc.subject - fr
- Fruit
- Maladie
- dc.subject.en - en
- Fruits
- Diseases
- dc.subject.fr - fr
- Fruit
- Maladie
- dc.title - en
- Lingonberry improves non-alcoholic fatty liver disease by reducing hepatic lipid accumulation, oxidative stress and inflammatory response
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 565
- local.article.journalissue
- 4
- local.article.journaltitle - en
- Antioxidants
- local.article.journalvolume
- 10
- local.pagination
- 1-15
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
- local.requestdoi - en
- No
- local.requestdoi - fr
- No
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