Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants
Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants
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- creativework.keywords - en
- Immunology
- Virology
- dc.contributor.author
- Parham, Kate A.
- Kim, Gyoung Nyoun
- Richer, Connor G.
- Ninkov, Marina
- Wu, Kunyu
- Saeedian, Nasrin
- Li, Yue
- Rashu, Rasheduzzaman
- Barr, Stephen D.
- Arts, Eric J.
- Haeryfar, S. M. Mansour
- Kang, C. Yong
- Troyer, Ryan M.
- dc.date.accessioned
- 2024-03-04T18:34:19Z
- dc.date.available
- 2024-03-04T18:34:19Z
- dc.date.issued
- 2023-02-28
- dc.description.abstract - en
- HIGHLIGHTS Produced replication-competent rVSV-based vaccines with variant SARS-CoV-2 spikes Variant vaccines elicited potent nAbs against diverse SARS-CoV-2 strains Delta booster and Trivalent vaccines were superior to the original Wuhan spike vaccine All vaccines elicited a spike-specific immunodominant CD8+ T cell response SUMMARY Recombinant vesicular stomatitis virus (rVSV) vaccines expressing spike proteins of Wuhan, Beta, and/or Delta variants of SARS-CoV-2 were generated and tested for induction of antibody and T cell immune responses following intramuscular delivery to mice. rVSV-Wuhan and rVSV-Delta vaccines and an rVSV-Trivalent (mixed rVSV-Wuhan, -Beta, -Delta) vaccine elicited potent neutralizing antibodies (nAbs) against live SARS-CoV-2 Wuhan (USAWA1), Beta (B.1.351), Delta (B.1.617.2), and Omicron (B.1.1.529) viruses. Prime-boost vaccination with rVSV-Beta was less effective in this capacity. Heterologous boosting of rVSV-Wuhan with rVSV-Delta induced strong nAb responses against Delta and Omicron viruses, with the rVSV-Trivalent vaccine consistently effective in inducing nAbs against all the SARS-CoV-2 variants tested. All vaccines, including rVSV-Beta, elicited a spike-specific immunodominant CD8+ T cell response. Collectively, rVSV vaccines targeting SARS-CoV-2 variants of concern may be considered in the global fight against COVID-19.
- dc.identifier.citation
- Parham KA, Kim GN, Richer CG, et al. Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants. iScience. 2023;26(4):106292. doi:https://doi.org/10.1016/j.isci.2023.106292
- dc.identifier.doi
- https://doi.org/10.1016/j.isci.2023.106292
- dc.identifier.issn
- 2589-0042
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1984
- dc.language.iso
- en
- dc.publisher
- CellPress
- dc.relation.isversionof - en
- https://open-science.canada.ca/handle/123456789/1935
- dc.rights - en
- Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
- dc.rights - fr
- Creative Commons Attribution - Pas d'utilisation commerciale - Pas de modification 4.0 International (CC BY-NC-ND 4.0)
- dc.rights.openaccesslevel - en
- Gold
- dc.rights.openaccesslevel - fr
- Or
- dc.rights.uri - en
- https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 106292
- local.article.journalissue
- 4
- local.article.journaltitle
- iScience
- local.article.journalvolume
- 26
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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