Practical guidance for clinical laboratories for SARS-CoV-2 serology testing
- DOI
- Language of the publication
- English
- Date
- 2021-04
- Type
- Article
- Author(s)
- Charlton, Carmen
- Kanji, Jamil
- Tran, Vanessa
- Kus, Julianne
- Gubbay, Jonathan
- Osiowy, Carla
- Robinson, Jason
- Sekirov, Inna
- Drebot, Michael
- Hatchette, Todd
- Stein, Derek
- El-Gabalawy, Nadia
- Lang, Amanda
- Jiao, Lei
- Levett, Paul
- Wood, Heidi
- Therrien, Christian
- Lindsay, Robbin
- Morshed, Muhammad
- Forbes, Jessica
- Dibernardo, Antonia
- Publisher
- Public Health Agency of Canada
Abstract
The landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing is rapidly evolving. While serology testing has limited diagnostic capacity for acute infection, its role in providing population-based information on positivity rates and informing evidence-based decision making for public health recommendations is increasing. With the global availability of vaccines, there is increasing pressure on clinical laboratories to provide antibody screening and result interpretation for vaccinated and non-vaccinated individuals. Here we present the most up-to-date data on SARS-CoV-2 antibody timelines, including the longevity of antibodies, and the production and detection of neutralizing antibodies. Additionally, we provide practical guidance for clinical microbiology laboratories to both verify commercial serology assays and choose appropriate testing algorithms for their local populations
Subject
- Health,
- Coronavirus diseases,
- Diagnosis
Rights
Pagination
171–83
Peer review
Yes
Identifiers
- ISSN
- 1481-8531
Article
- Journal title
- Canada Communicable Disease Report
- Journal volume
- 47
- Journal issue
- 4
Relation
- Is translation of:
- https://open-science.canada.ca/handle/123456789/3000
Citation(s)
Charlton CL, Kanji JN, Tran V, Kus JV, Gubbay J, Osiowy C, Robinson JL, Sekirov I, Drebot M, Hatchette T, Stein DR, El-Gabalawy N, Lang A, Jiao L, Levett PN, Wood H, Therrien C, Lindsay LR, Morshed M, Forbes JD, Dibernardo A on behalf of the Canadian Public Health Laboratory Network (CPHLN) Serology Working Group. Practical guidance for clinical laboratories for SARS-CoV-2 serology testing. Can Commun Dis Rep 2021;47(4):171–83. https://doi.org/10.14745/ccdr.v47i04a01