Patient-reported health outcomes of SARS-CoV-2–tested patients presenting to emergency departments : a propensity score–matched prospective cohort study
- DOI
- Language of the publication
- English
- Date
- 2023-02
- Type
- Article
- Author(s)
- Bola, R.
- Sutherland, J.
- Murphy, R. A.
- Leeies, M.
- Grant, L.
- Hayward, J.
- Archambault, P.
- Graves, L.
- Rose, T.
- Hohl, C.
- Publisher
- Elsevier Ltd on behalf of The Royal Society for Public Health
Abstract
Objective Study design Methods Results Conclusion
This study aimed to compare the long-term physical and mental health outcomes of matched severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive and SARS-CoV-2–negative patients controlling for seasonal effects.
This was a retrospective cohort study.
This study enrolled patients presenting to emergency departments participating in the Canadian COVID-19 Emergency Department Rapid Response Network. We enrolled consecutive eligible consenting patients who presented between March 1, 2020, and July 14, 2021, and were tested for SARS-CoV-2. Research assistants randomly selected four site and date-matched SARS-CoV-2–negative controls for every SARS-CoV-2–positive patient and interviewed them at least 30 days after discharge. We used propensity scores to match patients by baseline characteristics and used linear regression to compare Veterans RAND 12-item physical health component score (PCS) and mental health component scores (MCS), with higher scores indicating better self-reported health.
We included 1170 SARS-CoV-2–positive patients and 3716 test-negative controls. The adjusted mean difference for PCS was 0.50 (95% confidence interval [CI]: -0.36, 1.36) and -1.01 (95% CI: -1.91, -0.11) for MCS. Severe disease was strongly associated with worse PCS (β = −7.4; 95% CI: -9.8, -5.1), whereas prior mental health illness was strongly associated with worse MCS (β = −5.4; 95% CI: -6.3, -4.5).
Physical health, assessed by PCS, was similar between matched SARS-CoV-2–positive and SARS-CoV-2–negative patients, whereas mental health, assessed by MCS, was worse during a time when the public experienced barriers to care. These results may inform the development and prioritization of support programs for patients.
Subject
- Health,
- Coronavirus diseases
Rights
Pagination
1-11
Peer review
Yes
Identifiers
- PubMed ID
- 36587446
- ISSN
- 1476-5616
Article
- Journal title
- Public Health
- Journal volume
- 215
Sponsors
The Canadian Institutes of Health Research (447,679, 464,947, and 466,880), Ontario Ministry of Colleges and Universities (C-655-2129), Saskatchewan Health Research Foundation (5357), Genome BC (COV024 and VAC007), Fondation du CHU de Québec (Octroi No. 4007), and Sero-Surveillance and Research (COVID-19 Immunity Task Force Initiative) provided peer-reviewed funding. The BC Academic Health Science Network and BioTalent Canada provided non–peer-reviewed funding.