Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa
Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa
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Full item details
- creativework.keywords - en
- SARS-CoV-2
- COVID-19
- Antigen
- Sensitivity
- Specificity
- Omicron
- BA.4
- BA.5
- dc.contributor.author
- Samsunder, Natasha
- Lustig, Gila
- de Vos, Margaretha
- Ngcapu, Sinaye
- Giandhari, Jennifer
- Tshiabuila, Derek
- San, Emmanuel James
- Lewis, Lara
- Kharsany, Ayesha B. M.
- Cawood, Cherie
- de Oliveira, Tulio
- Sivro, Aida
- Abdool Karim, Quarraisha
- Escadafal, Camille
- Naidoo, Kogieleum
- Abdool Karim, Salim
- dc.date.accessioned
- 2023-09-29T16:28:01Z
- dc.date.available
- 2023-09-29T16:28:01Z
- dc.date.issued
- 2023-08
- dc.description.abstract - en
- BACKGROUND: Concerns around accuracy and performance of rapid antigen tests continue to be raised with the emergence of new SARS-CoV-2 variants. OBJECTIVE: To evaluate the performance of two widely used SARS-CoV-2 rapid antigen tests during BA.4/BA.5 SARS-CoV-2 wave in South Africa (May - June 2022). STUDY DESIGN: A prospective field evaluation compared the SARS-CoV-2 Antigen Rapid test from Hangzhou AllTest Biotech (nasal swab) and the Standard Q COVID-19 Rapid Antigen test from SD Biosensor (nasopharyngeal swab) to the Abbott RealTime SARS-CoV-2 assay (nasopharyngeal swab) on samples collected from 540 study participants. RESULTS: Overall 28.52% (154/540) were SARS-CoV-2 RT-PCR positive with median cycle number value of 12.30 (IQR 9.30-19.40). Out of the 99 successfully sequenced SARS-CoV-2 positive samples, 18 were classified as BA.4 and 56 were classified as BA.5. The overall sensitivities of the AllTest SARS-CoV-2 Ag test and Standard Q COVID-19 Ag test were 73.38% (95% CI 65.89-79.73) and 74.03% (95% CI 66.58-80.31) and their specificities were 97.41% (95% CI 95.30-98.59) and 99.22% (95% CI 97.74-99.74) respectively. Sensitivity was >90% when the cycle number value was 90% in samples infected with Omicron sub-lineage BA.4 and BA.5. CONCLUSION: Accuracy of tested rapid antigen tests that target the nucleocapsid SARS-CoV-2 protein, were not adversely affected by BA.4 and BA.5 Omicron sub-variants."
- dc.identifier.citation
- Samsunder, N., Lustig, G., de Vos, M., Ngcapu, S., Giandhari, J., Tshiabuila, D., San, E. J., Lewis, L., Kharsany, A. B., Cawood, C., de Oliveira, T., Abdool Karim, Q., Abdool Karim, S., Escadafal, C., Naidoo, K., & Sivro, A. (2023). Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 165, 105498. https://doi.org/10.1016/j.jcv.2023.105498
- dc.identifier.doi
- https://doi.org/10.1016/j.jcv.2023.105498
- dc.identifier.issn
- 1386-6532
- dc.identifier.other
- PMC10236920
- dc.identifier.pubmedID
- 37329842
- dc.identifier.uri
- https://open-science.canada.ca/handle/123456789/1183
- dc.language.iso
- en
- dc.publisher
- Pan American Society for Clinical Virology
- dc.rights - en
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights - fr
- Creative Commons Attribution 4.0 International (CC BY 4.0)
- dc.rights.uri - en
- https://creativecommons.org/licenses/by/4.0/
- dc.rights.uri - fr
- https://creativecommons.org/licenses/by/4.0/deed.fr
- dc.subject - en
- Health
- dc.subject - fr
- Santé
- dc.subject.en - en
- Health
- dc.subject.fr - fr
- Santé
- dc.title - en
- Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa
- dc.type - en
- Article
- dc.type - fr
- Article
- local.acceptedmanuscript.articlenum
- 105498
- local.article.journaltitle
- Journal of clinical virology
- local.article.journalvolume
- 165
- local.peerreview - en
- Yes
- local.peerreview - fr
- Oui
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