The strength in numbers : comprehensive characterization of house dust using complementary mass spectrometric techniques

Rostkowski, Pawel; Haglund, Peter; Aalizadeh, Reza; Alygizakis, Nikiforos; Thomaidis, Nikolaos; Beltran Arandes, Joaquin; Bohlin Nizzetto, Pernilla; Booij, Petra; Budzinski, Hélène; Brunswick, Pamela; Covaci, Adrian; Gallampois, Christine; Grosse, Sylvia; Hindle, Ralph; Ipolyi, Ildiko; Jobst, Karl; Kaserzon, Sarit L.; Leonards, Pim; Lestremau, Francois; Letzel, Thomas; Magnér, Jörgen; Matsukami, Hidenori; Moschet, Christoph; Oswald, Peter; Plassmann, Merle; Slobodnik, Jaroslav; Yang, Chun

The strength in numbers : comprehensive characterization of house dust using complementary mass spectrometric techniques

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dc.contributor.author: Rostkowski, Pawel; Haglund, Peter; Aalizadeh, Reza; Alygizakis, Nikiforos; Thomaidis, Nikolaos; Beltran Arandes, Joaquin; Bohlin Nizzetto, Pernilla; Booij, Petra; Budzinski, Hélène; Brunswick, Pamela; Covaci, Adrian; Gallampois, Christine; Grosse, Sylvia; Hindle, Ralph; Ipolyi, Ildiko; Jobst, Karl; Kaserzon, Sarit L.; Leonards, Pim; Lestremau, Francois; Letzel, Thomas; Magnér, Jörgen; Matsukami, Hidenori; Moschet, Christoph; Oswald, Peter; Plassmann, Merle; Slobodnik, Jaroslav; Yang, Chun
dc.date.accepted: 2019-01-15
dc.date.accessioned: 2025-07-04T19:21:16Z
dc.date.available: 2025-07-04T19:21:16Z
dc.date.issued: 2019-03-04
dc.date.submitted: 2018-11-06
dc.description.abstract - en: Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GC×GC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants.
dc.identifier.doi: https://doi.org/10.1007/s00216-019-01615-6
dc.identifier.issn: 1618-2650; 1618-2642
dc.identifier.uri: https://open-science.canada.ca/handle/123456789/3724
dc.language.iso: en
dc.publisher - en: Springer Nature
dc.rights - en: Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights - fr: Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.openaccesslevel - en: Gold
dc.rights.openaccesslevel - fr: Or
dc.rights.uri - en: https://creativecommons.org/licenses/by/4.0/
dc.rights.uri - fr: https://creativecommons.org/licenses/by/4.0/deed.fr
dc.subject - en: Chemistry; Pollutants; Environmental protection
dc.subject - fr: Chimie; Polluant; Protection de l'environnement
dc.subject.en - en: Chemistry; Pollutants; Environmental protection
dc.subject.fr - fr: Chimie; Polluant; Protection de l'environnement
dc.title - en: The strength in numbers : comprehensive characterization of house dust using complementary mass spectrometric techniques
dc.type - en: Article
dc.type - fr: Article
local.article.journaltitle - en: Analytical and Bioanalytical Chemistry
local.article.journalvolume: 411
local.pagination: 1957–1977
local.peerreview - en: Yes
local.peerreview - fr: Oui
local.requestdoi: No