Three separate acquisitions of blaNDM-1 in three different bacterial species from a single patient
- DOI
- Language of the publication
- English
- Date
- 2023-09-09
- Type
- Article
- Author(s)
- Mataseje, L. F.
- Pitout, J.
- Croxen, M.
- Mulvey, M. R.
- Dingle, T. C.
- Publisher
- Springer Nature
Abstract
To investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa, Acinetobacter baumannii; Ab and Proteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected; blaVIM-1 (Pa; ST773), blaOXA-23 (Ab, ST499) and blaNDM-1 identified in all isolates. NDM regions were found chromosomally integrated in all isolates. Data showed no evidence of NDM-1 transfer within this patient suggesting the enzyme was acquired in three separate events.
Subject
- Health
Keywords
- Carbapenemases,
- Canada,
- New Delhi metallo-beta-lactamase,
- Pseudomonas,
- Acientobacter,
- Proteus
Rights
Pagination
1275-1280
Peer review
Yes
Open access level
Gold
Identifiers
- PubMed ID
- 37688673
- ISSN
- 0934-9723
- Other
- PMC10511597
Article
- Journal title
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Journal volume
- 42
- Journal issue
- 10
Citation(s)
Mataseje, L. F., Pitout, J., Croxen, M., Mulvey, M. R., & Dingle, T. C. (2023). Three separate acquisitions of blaNDM-1 in three different bacterial species from a single patient. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 42(10), 1275–1280. https://doi.org/10.1007/s10096-023-04651-4