Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex

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DOI

https://doi.org/10.1016/j.jinf.2024.106163

Language of the publication
English
Date
2024-06
Type
Article
Author(s)
  • Tsang, Raymond S.W.
  • Deceuninck, Genevieve
  • Meilleur, Courtney
  • Zhou, Jianwei
  • Lefebvre, Brigitte
  • De Wals, Philippe
Publisher
Elsevier Ltd on behalf of The British Infection Association

Abstract

Objective
To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains.

Methods
IMD cases and MenY strains from January 1, 2015 to August 11, 2023 were analyzed for clonal analysis and prediction of susceptibility to MenB vaccines. MenY strains of ST-23 CC from Quebec were analyzed with global MenY strains by core-genomic multi-locus sequence typing (cg-MLST).

Results
Since 2015 the serogroup distribution of IMD in Quebec has shifted from predominantly MenB to mainly MenY, with most (80.9 %) of the latter belonging to ST-23 CC. The median age of MenY cases due to ST-23 CC were statistically younger than MenY cases due to non-ST-23 CC. MenY of ST-23 CC showed genetic diversity and the major genetic cluster were similar to the Swedish Y1 strain. The increase in invasive MenY disease in Quebec was due to a sub-clade of Lineage 23.1 which caused an elevated proportion of severe disease in young adults.

Conclusion
The increase in invasive MenY disease in Quebec, Canada was driven by the expansion of a sub-clade of Lineage 23.1 in young adults. Currently available quadrivalent A,C,W,Y-conjugate meningococcal vaccines were predicted to provide protection against these strains.

Subject

  • Health,
  • Epidemiology,
  • Immunization

Rights

Pagination

1-8

Peer review

Yes

Open access level

Gold

Identifiers

PubMed ID
38670267
ISSN
0163-4453

Article

Journal title
Journal of Infection
Journal volume
88
Journal issue
6
Article number
106163

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Collection(s)

Public health surveillance

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