Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex
- DOI
- Language of the publication
- English
- Date
- 2024-06
- Type
- Article
- Author(s)
- Tsang, Raymond S.W.
- Deceuninck, Genevieve
- Meilleur, Courtney
- Zhou, Jianwei
- Lefebvre, Brigitte
- De Wals, Philippe
- Publisher
- Elsevier Ltd on behalf of The British Infection Association
Abstract
Objective Methods Results Conclusion
To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains.
IMD cases and MenY strains from January 1, 2015 to August 11, 2023 were analyzed for clonal analysis and prediction of susceptibility to MenB vaccines. MenY strains of ST-23 CC from Quebec were analyzed with global MenY strains by core-genomic multi-locus sequence typing (cg-MLST).
Since 2015 the serogroup distribution of IMD in Quebec has shifted from predominantly MenB to mainly MenY, with most (80.9 %) of the latter belonging to ST-23 CC. The median age of MenY cases due to ST-23 CC were statistically younger than MenY cases due to non-ST-23 CC. MenY of ST-23 CC showed genetic diversity and the major genetic cluster were similar to the Swedish Y1 strain. The increase in invasive MenY disease in Quebec was due to a sub-clade of Lineage 23.1 which caused an elevated proportion of severe disease in young adults.
The increase in invasive MenY disease in Quebec, Canada was driven by the expansion of a sub-clade of Lineage 23.1 in young adults. Currently available quadrivalent A,C,W,Y-conjugate meningococcal vaccines were predicted to provide protection against these strains.
Subject
- Health,
- Epidemiology,
- Immunization
Rights
Pagination
1-8
Peer review
Yes
Open access level
Gold
Identifiers
- PubMed ID
- 38670267
- ISSN
- 0163-4453
Article
- Journal title
- Journal of Infection
- Journal volume
- 88
- Journal issue
- 6
- Article number
- 106163