COVID-19 seroprevalence in Canada modelling waning and boosting COVID-19 immunity in Canada a Canadian Immunization Research Network study

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creativework.keywords - en
seroprevalence
COVID-19
infectious disease modelling
mathematical epidmiology
dc.contributor.author
Dick, David W.
Childs, Lauren
Feng, Zhilan
Li, Jing
Röst, Gergely
Buckeridge, David L.
Ogden, Nick H.
Heffernan, Jane M.
dc.date.accessioned
2024-03-08T18:54:15Z
dc.date.available
2024-03-08T18:54:15Z
dc.date.issued
2021-12-23
dc.description.abstract - en
COVID-19 seroprevalence changes over time, with infection, vaccination, and waning immunity. Seroprevalence estimates are needed to determine when increased COVID-19 vaccination coverage is needed, and when booster doses should be considered, to reduce the spread and disease severity of COVID-19 infection. We use an age-structured model including infection, vaccination and waning immunity to estimate the distribution of immunity to COVID-19 in the Canadian population. This is the first mathematical model to do so. We estimate that 60–80% of the Canadian population has some immunity to COVID-19 by late Summer 2021, depending on specific characteristics of the vaccine and the waning rate of immunity. Models results indicate that increased vaccination uptake in age groups 12–29, and booster doses in age group 50+ are needed to reduce the severity COVID-19 Fall 2021 resurgence.
dc.identifier.doi
https://doi.org/10.3390/vaccines10010017
dc.identifier.issn
2076-393X
dc.identifier.pubmedID
35062678
dc.identifier.uri
https://open-science.canada.ca/handle/123456789/2036
dc.language.iso
en
dc.publisher
MDPI
dc.rights - en
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights - fr
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.openaccesslevel - en
Gold
dc.rights.openaccesslevel - fr
Or
dc.rights.uri - en
https://creativecommons.org/licenses/by/4.0/
dc.rights.uri - fr
https://creativecommons.org/licenses/by/4.0/deed.fr
dc.subject - en
Health
dc.subject - fr
Santé
dc.subject.en - en
Health
dc.subject.fr - fr
Santé
dc.title - en
COVID-19 seroprevalence in Canada modelling waning and boosting COVID-19 immunity in Canada a Canadian Immunization Research Network study
dc.type - en
Article
dc.type - fr
Article
local.acceptedmanuscript.articlenum
17
local.article.journalissue
1
local.article.journaltitle
Vaccines
local.article.journalvolume
10
local.pagination
1-19
local.peerreview - en
Yes
local.peerreview - fr
Oui
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