Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
- DOI
- Language of the publication
- English
- Date
- 2019-11-01
- Type
- Article
- Author(s)
- Graf, Daniela
- Monk, Jennifer M.
- Wu, Wenqing
- Wellings, Hannah R.
- Robinson, Lindsay E.
- Power, Krista A.
- Publisher
- Elsevier
Alternative title
Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice
Abstract
Lentils (Lens culinaris L.) are a protein-rich plant food, also enriched in fibre and phenolic compounds that may reduce intestinal-associated disease risk. Male C57Bl/6 mice were pre-fed a basal diet (BD) or isocaloric 20% red lentil-supplemented diet (LD) for 3 weeks and acute colitis was induced via dextran sodium sulfate (DSS, 2% w/v in drinking water) for 5 days. LD-fed mice exhibited reduced (i) clinical symptoms, (ii) colon histological damage, and (iii) colonic pro-inflammatory cytokine levels. Additionally, biomarkers of improved colon epithelial barrier integrity and mucosal repair mediators were increased in LD mice (e.g. colonic IL-22, Relmβ, and occludin expression, and serum lipopolysaccharide binding protein). Collectively, the severity of the DSS-induced acute colitis phenotype in mice was attenuated by red lentil dietary supplementation, indicating that lentils may serve as a potential adjuvant dietary therapy in patients with colitis-associated diseases to help limit colonic inflammation and restore barrier function.
Subject
- Agriculture
Keywords
- lentils,
- pulses,
- colitis,
- inflammation,
- cytokines,
- Dextran sodium sulfate
Peer review
Yes
Open access level
Gold
Identifiers
- ISSN
- 2214-9414
Article
- Journal title
- Journal of Functional Foods
- Journal volume
- 64
Citation(s)
Graf, D., Monk, J., Wu, W., Wellings H., Robinson, L., & Power, K. (2020). Red lentil supplementation reduces the severity of dextran sodium sulfate-induced colitis in C57BL/6 male mice. Journal of Functional Foods, 64,103625, https://doi.org/10.1016/j.jff.2019.103625